Mouse Monoclonal KIF1B Antibody

The KIF1B antibody is a tool used to detect KIF1B, a member of the kinesin superfamily of motor proteins involved in intracellular transport. KIF1B plays critical roles in neuronal function, particularly in the anterograde transport of mitochondria and synaptic vesicles along microtubules. It exists in two major isoforms, KIF1Bα and KIF1Bβ, generated through alternative splicing. KIF1Bβ is specifically associated with the transport of synaptic vesicle precursors, while KIF1Bα is implicated in mitochondrial trafficking. Dysregulation of KIF1B has been linked to neurological disorders, such as Charcot-Marie-Tooth disease, and cancer, including neuroblastoma and pheochromocytoma. Notably, germline mutations in the KIF1B gene have been identified as risk factors for these cancers, highlighting its tumor-suppressive role. The KIF1B antibody is widely utilized in research to study protein expression, localization, and functional mechanisms in both physiological and pathological contexts. It aids in elucidating KIF1B's involvement in cellular processes, disease pathways, and potential therapeutic targets. Commercial KIF1B antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, though specificity and isoform recognition may vary. Ongoing studies continue to explore its biomarker potential and regulatory networks in neurodegeneration and oncology.