Rabbit Polyclonal CALY Antibody

The CALY antibody targets calcyon, a neuronal protein encoded by the CALY gene (also known as CALY or DKFZp434L187), primarily expressed in the brain. Calcyon interacts with dopamine D1 receptors and plays a role in modulating dopaminergic signaling, particularly in the prefrontal cortex and striatum. It is implicated in regulating synaptic plasticity, cognitive functions, and reward pathways. Research highlights its involvement in neuropsychiatric disorders such as schizophrenia, attention deficit hyperactivity disorder (ADHD), and addiction, where dopaminergic dysregulation is a key feature. CALY antibodies are used in neuroscience to study protein localization, expression levels, and interactions in neuronal tissues or cell models. They aid in elucidating calcyon's role in receptor trafficking, intracellular signaling, and its impact on behavior and disease mechanisms. Studies using these antibodies have contributed to understanding how calcyon affects glutamate receptor activity and cross-talk between dopaminergic and glutamatergic systems. CALY antibodies are typically validated via Western blot, immunohistochemistry, and immunofluorescence, showing specificity for the ~25 kDa protein. Their application spans both basic research and translational studies aiming to develop therapeutic strategies targeting dopamine-associated neurological and psychiatric conditions.