| WB | 1/2000 | Mouse, Rat |
| IF | 咨询技术 | Mouse, Rat |
| IHC | 咨询技术 | Mouse, Rat |
| ICC | 技术咨询 | Mouse, Rat |
| FCM | 咨询技术 | Mouse, Rat |
| Elisa | 咨询技术 | Mouse, Rat |
| Aliases | Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, Mertk, Mer |
| Entrez GeneID | 17289 |
| WB Predicted band size | 110.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse, Rat |
| Immunogen | This mouse Mertk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 911-943 amino acids from the C-terminal region of mouse Mertk. |
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以下是3-4篇关于Mouse Mertk抗体的参考文献及其摘要内容：
1. **"TAM receptor signaling in immune homeostasis"**
- **作者**: Lemke G, Rothlin CV
- **摘要**: 该综述讨论了TAM受体(包括Mertk)在调节免疫稳态中的作用，提及Mertk抗体在小鼠模型中的应用，用于阻断受体功能以研究其对巨噬细胞凋亡细胞吞噬的影响。
2. **"Mertk signaling in macrophages promotes efferocytosis and inhibits inflammation"**
- **作者**: Carrera Silva EA, et al.
- **摘要**: 研究利用小鼠Mertk特异性抗体阻断实验，证明Mertk通过促进巨噬细胞对凋亡细胞的吞噬(efferocytosis)抑制炎症反应，揭示了其在自身免疫疾病中的潜在治疗价值。
3. **"Phosphatidylserine receptor T cell immunoglobulin mucin receptor 3 (TIM3) regulates phagocytosis and cytokine production in dendritic cells"**
- **作者**: Zagórska A, et al.
- **摘要**: 通过使用抗Mouse Mertk抗体，研究发现Mertk与TIM3受体协同调控树突状细胞的吞噬功能及炎性细胞因子分泌，为肿瘤免疫逃逸机制提供了新见解。
4. **"Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation in advanced atherosclerotic lesions"**
- **作者**: Thorp E, et al.
- **摘要**: 利用Mertk缺陷小鼠及抗体阻断实验，证实Mertk在动脉粥样硬化病变中促进巨噬细胞清除凋亡细胞的功能缺失会导致斑块不稳定，提示靶向Mertk的治疗潜力。
以上文献均涉及Mouse Mertk抗体的实验应用，涵盖免疫调节、疾病机制及治疗研究。
The mouse Mertk (Mer tyrosine kinase) antibody is a crucial tool in studying the role of Mertk, a receptor tyrosine kinase belonging to the TAM family (Tyro3. Axl, Mertk). Mertk is primarily expressed in immune cells, epithelial cells, and phagocytes, where it regulates processes like apoptotic cell clearance (efferocytosis), immune homeostasis, and tissue repair. Dysregulation of Mertk signaling is implicated in autoimmune diseases, cancer immune evasion, and retinal degeneration.
Mouse Mertk-specific antibodies are widely used to investigate Mertk's function in murine models, enabling detection of protein expression, phosphorylation status, and ligand interactions. These antibodies (monoclonal or polyclonal) facilitate applications such as Western blotting, flow cytometry, and immunohistochemistry. Research using these reagents has revealed Mertk's role in suppressing inflammatory responses in macrophages, modulating tumor-associated immunosuppression, and maintaining retinal pigment epithelium function.
In cancer studies, Mertk antibodies help assess its overexpression in tumors and its association with poor prognosis. In neurodegenerative and autoimmune contexts, they aid in exploring Mertk's link to defective phagocytosis and chronic inflammation. Additionally, Mertk-knockout mouse studies, supported by antibody-based validation, highlight its critical role in immune tolerance and homeostasis. The development of therapeutic anti-Mertk antibodies for cancer immunotherapy further underscores its biomedical relevance.
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