| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Semaphorin-4B, SEMA4B, KIAA1745, SEMAC |
| Entrez GeneID | 10509 |
| WB Predicted band size | 92.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This SEMA4B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 371-405 amino acids from the C-terminal region of human SEMA4B. |
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以下是关于SEMA4B抗体的3篇代表性文献的简要概括(基于已有研究背景，非实时检索结果)：
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1. **文献名称**: *SEMA4B promotes glioma progression by activating AKT/ERK/STAT3 signaling pathways*
**作者**: Nakamura S. et al.
**摘要**: 该研究通过免疫组化(使用SEMA4B抗体)发现SEMA4B在胶质瘤组织中高表达，并通过体外实验证明其通过激活AKT/ERK/STAT3通路促进肿瘤侵袭和增殖。
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2. **文献名称**: *Semaphorin 4B as a biomarker for breast cancer metastasis*
**作者**: Li Y. et al.
**摘要**: 研究利用SEMA4B特异性抗体检测乳腺癌患者组织样本，发现SEMA4B表达水平与淋巴结转移和不良预后显著相关，提示其作为潜在转移标志物的价值。
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3. **文献名称**: *SEMA4B regulates T-cell immune responses through CD72 interaction*
**作者**: Kumanogoh A. et al.
**摘要**: 通过流式细胞术和免疫沉淀(使用SEMA4B抗体)，揭示了SEMA4B在免疫系统中通过结合CD72受体调控T细胞活化和自身免疫反应的分子机制。
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注：以上文献信息为示例性质，实际文献需通过PubMed或Google Scholar检索确认。如需具体文章，建议使用关键词"SEMA4B antibody"或"SEMA4B function"结合领域限定(如癌症、神经科学)进行精准查询。
The SEMA4B antibody is a research tool designed to detect and study semaphorin-4B (SEMA4B), a transmembrane protein belonging to the semaphorin family. Semaphorins are evolutionarily conserved signaling molecules involved in diverse biological processes, including axon guidance, immune regulation, angiogenesis, and tumor progression. SEMA4B, encoded by the SEMA4B gene in humans, interacts with receptors such as plexins and Met to modulate intracellular signaling pathways, influencing cell adhesion, migration, and apoptosis. It plays roles in neural development, immune response modulation, and tissue homeostasis. Dysregulation of SEMA4B has been implicated in cancers (e.g., breast, lung, and gliomas), neurological disorders, and autoimmune diseases, making it a potential therapeutic or diagnostic target.
SEMA4B antibodies are typically produced in hosts like rabbits or mice using immunogenic peptide sequences specific to SEMA4B. These antibodies enable researchers to investigate SEMA4B expression patterns via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They are critical for elucidating SEMA4B's functional roles in disease models, validating its interaction partners, and exploring its therapeutic relevance. Validation steps (e.g., knockout controls) ensure specificity, as cross-reactivity with other semaphorins remains a concern. Commercial SEMA4B antibodies often include datasheets detailing applications, species reactivity, and recommended experimental conditions, aiding reproducibility in research.
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