Rabbit Polyclonal MouseInsr(P1325) Antibody

The Mouse Insulin Receptor (INSR) antibody, particularly targeting the phosphorylated form at residue P1325 (Tyr1325), is a critical tool for studying insulin signaling pathways. The insulin receptor (INSR) is a transmembrane tyrosine kinase receptor composed of two α- and two β-subunits. Upon insulin binding, the receptor undergoes autophosphorylation at specific tyrosine residues, including Tyr1325 in the β-subunit’s kinase domain, which activates downstream signaling cascades regulating glucose uptake, metabolism, and cell growth. The P1325 antibody is designed to detect this phosphorylated form, enabling researchers to study receptor activation dynamics. It is widely used in applications like Western blotting, immunohistochemistry, and ELISA to investigate insulin resistance mechanisms in conditions such as type 2 diabetes, obesity, and metabolic syndrome. Additionally, it aids in exploring INSR’s role in cancer, where aberrant signaling may promote tumor progression. This antibody’s specificity for the phosphorylated Tyr1325 site ensures accurate detection of activated INSR, making it valuable for both basic research and preclinical studies targeting insulin-related disorders.