Rabbit Polyclonal VAV3 Antibody

The VAV3 antibody is a crucial tool for studying the VAV3 protein, a member of the VAV family of guanine nucleotide exchange factors (GEFs) that activate Rho/Rac GTPases. First identified in the late 1990s, VAV3 plays a key role in intracellular signaling pathways regulating cell adhesion, motility, proliferation, and differentiation. It is activated by phosphorylation following stimulation of receptors like tyrosine kinases, integrins, and immune receptors. Structurally, VAV3 contains multiple domains, including a catalytic Dbl-homology (DH) domain, pleckstrin-homology (PH) domain, and regulatory motifs that control its GEF activity. Dysregulation of VAV3 has been implicated in cancer progression, particularly in hormone-related malignancies such as prostate and breast cancers, where overexpression correlates with metastasis and therapy resistance. Additionally, VAV3 interacts with pathways like PI3K/AKT and MAPK, influencing oncogenic signaling. Researchers employ VAV3 antibodies in techniques like Western blotting, immunohistochemistry, and flow cytometry to analyze its expression patterns, subcellular localization, and post-translational modifications. These studies help elucidate VAV3's role in tumor biology, immune responses, and neurodevelopmental processes, positioning it as a potential therapeutic target. Validated antibodies are essential for distinguishing VAV3 from homologous family members (VAV1/VAV2) due to conserved domains.