| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Frizzled-10, Fz-10, hFz10, FzE7, CD350, FZD10 |
| Entrez GeneID | 11211 |
| WB Predicted band size | 65.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FZD10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 177-212 amino acids from the N-terminal region of human FZD10. |
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以下是关于FZD10 (N-term)抗体的假设性参考文献示例，基于常见研究场景整理：
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1. **文献名称**: *Overexpression of FZD10 in Colorectal Cancer and Its Clinical Significance*
**作者**: Ueno K, et al.
**摘要**: 该研究通过免疫组化(使用FZD10 N-term抗体)发现FZD10在结直肠癌组织中高表达，并与患者预后不良相关。抗体特异性通过siRNA敲低验证，证实其在肿瘤发生中的作用。
2. **文献名称**: *FZD10 as a Diagnostic Marker for Synovial Sarcoma Using a Novel N-terminal Antibody*
**作者**: Terry J, et al.
**摘要**: 研究团队开发了针对FZD10 N端的单克隆抗体，用于滑膜肉瘤诊断。免疫组化显示该抗体在滑膜肉瘤中特异性染色，而在其他软组织肿瘤中无反应，支持其作为病理诊断工具。
3. **文献名称**: *Characterization of FZD10 Antibody for Wnt Signaling Pathway Studies*
**作者**: Saitoh T, et al.
**摘要**: 本文报道了兔源FZD10 N-term多克隆抗体的制备，验证其在Western Blot和免疫荧光中的应用，证实FZD10在多种癌细胞膜上的表达，并参与Wnt3a介导的信号激活。
4. **文献名称**: *Functional Blockade of FZD10 via N-terminal Antibody Inhibits Wnt5a-Driven Cell Invasion*
**作者**: Mikels AJ, et al.
**摘要**: 研究使用FZD10 N-term抗体阻断Wnt5a与受体的结合，证明其抑制黑色素瘤细胞侵袭的能力，提示靶向FZD10 N端可能成为治疗Wnt依赖性癌症的策略。
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**注**：以上文献为示例性内容，实际引用需根据真实研究调整。建议通过PubMed或Google Scholar以关键词“FZD10 antibody N-term”或“FZD10 N-terminal function”检索最新文献。
The FZD10 (N-term) antibody targets the N-terminal extracellular region of Frizzled-10 (FZD10), a member of the Frizzled family of Wnt signaling receptors. FZD proteins are critical components of the Wnt/β-catenin and non-canonical Wnt pathways, regulating cell proliferation, differentiation, and embryonic development. FZD10. a seven-transmembrane receptor, contains a conserved cysteine-rich domain (CRD) at its N-terminus, which mediates Wnt ligand binding and receptor activation. The N-term-specific antibody is designed to recognize epitopes within or near this functional CRD, enabling studies on FZD10 expression, localization, and interaction dynamics.
FZD10 is implicated in various cancers, including colorectal carcinoma and synovial sarcoma, where its overexpression correlates with tumor progression and metastasis. Research using this antibody has helped elucidate FZD10's role in Wnt pathway activation, particularly in contexts where aberrant signaling drives oncogenesis. The antibody is commonly utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess FZD10 protein levels in tissues or cell lines. Its specificity for the N-terminal region ensures minimal cross-reactivity with other FZD family members, making it a valuable tool for dissecting FZD10-specific functions in both physiological and pathological settings. Understanding FZD10's mechanisms via this antibody contributes to potential therapeutic strategies targeting Wnt-driven diseases.
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