Rabbit Polyclonal SEMA3E Antibody

The SEMA3E antibody is a tool used to detect and study semaphorin-3E (SEMA3E), a secreted glycoprotein belonging to the semaphorin family. SEMA3E plays critical roles in axonal guidance during neural development and has been implicated in vascular patterning, immune regulation, and cancer progression. It interacts primarily with the receptor Plexin D1. triggering downstream signaling pathways (e.g., Rho GTPases, MAPK) that regulate cell migration, adhesion, and cytoskeletal dynamics. In cancer, SEMA3E exhibits context-dependent functions: it can inhibit tumor angiogenesis by disrupting endothelial cell sprouting or promote metastasis by enhancing invasive cell behavior. The antibody is widely used in research applications like Western blotting, immunohistochemistry, and immunofluorescence to map SEMA3E expression patterns in tissues or disease models. It also aids in functional studies, such as blocking SEMA3E activity to explore its therapeutic potential. Commercially available SEMA3E antibodies are typically validated for specificity against the conserved Sema domain or C-terminal regions. Its study remains vital for understanding neurodevelopmental disorders, cardiovascular diseases, and cancer biology, particularly in contexts involving aberrant cell signaling and microenvironment interactions.