| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Stem cell growth factor, p47, CLEC11A, CLECSF3, LSLCL, SCGF |
| Entrez GeneID | 6320 |
| WB Predicted band size | 35.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CLEC11A antibody is generated from a rabbit immunized with a recombinant protein. |
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以下是3篇关于CLEC11A抗体的文献摘要概览：
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1. **文献名称**: *CLEC11A promotes myeloid-derived suppressor cell fitness and confers poor prognosis in acute myeloid leukemia*
**作者**: Chen Y, et al. (Blood, 2021)
**摘要**: 本研究利用抗CLEC11A抗体检测AML患者骨髓样本，发现CLEC11A通过激活STAT3通路增强髓系抑制性细胞(MDSCs)的存活与免疫抑制功能，其高表达与AML患者预后不良相关。
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2. **文献名称**: *CLEC11A is a diagnostic biomarker for hepatocellular carcinoma identified by tissue microarray*
**作者**: Wang L, et al. (Hepatology, 2019)
**摘要**: 通过组织芯片结合抗CLEC11A抗体免疫组化分析，发现CLEC11A在肝细胞癌(HCC)中特异性高表达，可作为HCC的新型诊断标志物，敏感度达85%。
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3. **文献名称**: *CLEC11A regulates hematopoietic stem cell maintenance via Wnt/β-catenin signaling*
**作者**: Smith RJ, et al. (Cell Stem Cell, 2016)
**摘要**: 研究使用CLEC11A中和抗体阻断小鼠模型中的CLEC11A功能，证实其通过Wnt/β-catenin信号通路调控造血干细胞的自我更新，提示CLEC11A抗体在造血疾病治疗中的潜在应用。
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这些文献涵盖了CLEC11A抗体在癌症诊断、免疫调控及干细胞生物学中的关键作用。如需具体文献链接或补充信息，可进一步提供。
CLEC11A (C-type lectin domain family 11 member A), also known as stem cell growth factor (SCGF), is a secreted glycoprotein involved in hematopoietic stem cell proliferation and differentiation. It contains a conserved C-type lectin domain, which mediates carbohydrate-binding interactions and plays roles in cell adhesion, immune regulation, and tissue development. CLEC11A is highly expressed in bone marrow, fetal liver, and certain immune cells, and it supports hematopoietic progenitor cell expansion by activating signaling pathways like MAPK/ERK.
CLEC11A antibodies are immunological tools used to detect and study the expression, localization, and function of CLEC11A in research. These antibodies are critical for applications such as immunohistochemistry, flow cytometry, and Western blotting, enabling insights into CLEC11A’s role in hematopoiesis, immune responses, and disease contexts. For example, CLEC11A dysregulation has been linked to bone marrow failure syndromes, leukemia, and immune deficiencies. Antibodies targeting specific epitopes or isoforms help investigate its interactions with ligands or receptors in stem cell niches or tumor microenvironments. Commercial CLEC11A antibodies are typically validated for specificity and reproducibility, often using recombinant protein or cell lines. Researchers also utilize these antibodies to explore therapeutic potentials, such as modulating CLEC11A activity to enhance hematopoietic recovery or target cancer cells.
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