Rabbit Polyclonal (DANRE)becn1 Antibody

The DANRE (Danio rerio) Becn1 antibody is a research tool designed to detect Beclin 1. a key autophagy-related protein, in zebrafish models. Beclin 1. encoded by the *becn1* gene, plays a central role in autophagosome formation and cellular homeostasis by interacting with Class III PI3K complexes. It regulates processes like apoptosis, tumor suppression, and immune responses. Zebrafish Becn1 shares high homology with mammalian orthologs, making it a valuable model for studying autophagy mechanisms in development and disease. The DANRE Becn1 antibody is typically generated using epitopes from conserved regions of zebrafish Beclin 1. validated through techniques like Western blotting, immunofluorescence, or knockout controls. Its applications include investigating autophagy dynamics during embryogenesis, neurodegeneration, or infection in zebrafish. Researchers use this antibody to visualize protein localization, quantify expression under stress conditions, or explore interactions with partners like UVRAG or ATG14. As zebrafish gain prominence in translational research, this antibody supports studies bridging autophagy dysfunction to human pathologies like cancer or metabolic disorders. Commercial variants often cite cross-reactivity with other vertebrate models, but species-specific validation remains critical.