Rabbit Polyclonal (DANRE)atg9a Antibody

The DANRE (Danio rerio) Atg9a antibody is a research tool specifically designed to detect the ATG9A protein in zebrafish models. ATG9A is a conserved transmembrane protein critical for autophagy, a cellular recycling process that degrades damaged organelles and misfolded proteins. In zebrafish, ATg9a facilitates autophagosome formation by shuttling membrane components to nascent autophagic vesicles, playing roles in development, stress adaptation, and disease modeling. This antibody is typically generated in hosts like rabbits or mice using immunogenic peptides derived from zebrafish ATG9A sequences. It enables researchers to study ATG9A expression, localization, and function through techniques like Western blotting, immunofluorescence, or immunohistochemistry in zebrafish embryos or tissues. Its applications span developmental biology, neurodegenerative disease studies (e.g., Alzheimer’s, Parkinson’s), and cancer research, where autophagy dysregulation is implicated. Validation often includes testing in wild-type versus *atg9a* knockout zebrafish to confirm specificity. The antibody’s utility lies in bridging molecular autophagy mechanisms with whole-organism physiology in a transparent, genetically tractable model. Key studies using this reagent have elucidated ATG9A’s role in zebrafish embryogenesis and lipid metabolism, providing evolutionary insights into autophagy regulation.