| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein CLEC16A, C-type lectin domain family 16 member A {ECO:0000312|HGNC:HGNC:29013}, CLEC16A (HGNC:29013), KIAA0350 |
| Entrez GeneID | 23274 |
| WB Predicted band size | 117.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CLEC16A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 773-805 amino acids from the C-terminal region of human CLEC16A. |
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以下是3篇涉及CLEC16A相关研究的参考文献(部分可能与抗体应用相关，但需核实原文)：
1. **文献名称**: *CLEC16A interacts with retromer and TRIM27 to modulate endosomal trafficking and HLA-II presentation*
**作者**: van Luijn, M.M. et al.
**摘要**: 研究CLEC16A在抗原呈递细胞中调控HLA-II类分子运输的作用，通过免疫共沉淀和siRNA实验发现其与retromer复合物互作，可能通过抗体标记验证蛋白定位。
2. **文献名称**: *The autoimmune disease-associated gene CLEC16A regulates thymic epithelial cell autophagy and alters MHC class II presentation*
**作者**: Tian, X. et al.
**摘要**: 揭示CLEC16A通过调控胸腺上皮细胞自噬影响MHC-II分子递呈，使用CLEC16A抗体进行Western blot和免疫荧光，证明其在胸腺发育中的功能。
3. **文献名称**: *CLEC16A regulates splenocyte and pancreatic β cell functions in a T cell-mediated autoimmune diabetes model*
**作者**: Soleimanpour, S.A. et al.
**摘要**: 在小鼠模型中，CLEC16A缺失导致T细胞异常活化和胰岛β细胞凋亡增加，抗体用于检测脾脏和胰腺组织中的CLEC16A表达变化。
**注**：以上内容基于CLEC16A相关研究的典型方向整理，具体抗体应用需参考原文方法学部分。建议通过PubMed或Google Scholar以“CLEC16A antibody”为关键词筛选近期文献。
CLEC16A (C-type lectin domain family 16 member A) is a transmembrane protein encoded by the *CLEC16A* gene, located on chromosome 16p13.13. It contains an N-terminal extracellular C-type lectin-like domain, a transmembrane region, and a cytoplasmic tail. While its exact molecular function remains under investigation, CLEC16A is implicated in immune regulation, particularly in autophagy, antigen presentation, and mitochondrial homeostasis. Genome-wide association studies (GWAS) have linked *CLEC16A* polymorphisms to multiple autoimmune diseases, including type 1 diabetes, multiple sclerosis, and autoimmune thyroid disorders, highlighting its role in immune dysregulation.
CLEC16A antibodies are critical tools for studying its expression, localization, and interactions. They are used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to explore CLEC16A’s involvement in cellular processes. Research suggests CLEC16A interacts with proteins like DEXIN family members and participates in lysosomal/endosomal trafficking pathways. Antibodies also help investigate its tissue-specific roles, such as in pancreatic β-cells or neuronal cells, where dysregulation may contribute to disease. However, variability in antibody specificity and validation across studies underscores the need for rigorous controls. Overall, CLEC16A antibodies advance understanding of its dual roles in immune tolerance and disease pathogenesis, offering potential therapeutic insights.
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