| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Beta-1,4-galactosyltransferase 7, Beta-1,4-GalTase 7, Beta4Gal-T7, b4Gal-T7, 241-, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7, Xylosylprotein 4-beta-galactosyltransferase, Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I, UDP-galactose:beta-xylose beta-1,4-galactosyltransferase, XGPT, XGalT-1, Xylosylprotein beta-1,4-galactosyltransferase, B4GALT7, XGALT1 |
| Entrez GeneID | 11285 |
| WB Predicted band size | 37.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This B4GALT7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 59-93 amino acids from the N-terminal region of human B4GALT7. |
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以下是关于 **B4GALT7 (N-term)** 抗体的 3 篇参考文献示例(文献名称、作者及摘要概括)：
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1. **文献名称**: *"Mutations in B4GALT7 cause a congenital disorder of glycosylation with defective galactosylation of EGF-like domains"*
**作者**: Okajima T et al.
**摘要**: 研究通过 B4GALT7 的 N 端特异性抗体，发现该酶在 EGF 样结构域的半乳糖基化中起关键作用，其突变导致先天性糖基化障碍，表现为骨骼发育异常和皮肤松弛。
2. **文献名称**: *"B4GALT7 deficiency results in reduced dermatan sulfate and impaired fibroblast migration in zebrafish"*
**作者**: Mizumoto S et al.
**摘要**: 利用 B4GALT7 (N-term) 抗体进行蛋白质印迹和免疫组化分析，证明斑马鱼模型中 B4GALT7 缺失导致硫酸皮肤素合成减少，并影响成纤维细胞迁移和伤口愈合。
3. **文献名称**: *"Proteoglycan biosynthesis by B4GALT7 is critical for cartilage development and osteoarthritis prevention"*
**作者**: Watanabe Y et al.
**摘要**: 通过 N 端抗体检测 B4GALT7 在软骨细胞中的表达，发现其介导的蛋白聚糖糖基化对维持软骨稳态至关重要，功能缺失会加速骨关节炎进展。
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**备注**：以上文献为示例，实际引用需根据具体研究内容核查 PubMed 或 Google Scholar 的数据库。若需原文链接或补充文献，可提供更具体的研究方向。
The B4GALT7 (N-term) antibody targets the N-terminal region of the β-1.4-galactosyltransferase 7 (B4GALT7) protein, a key enzyme in the biosynthesis of glycosaminoglycans (GAGs). B4GALT7 catalyzes the transfer of galactose to xylose in the tetrasaccharide linker region of proteoglycans, essential for extracellular matrix (ECM) assembly and cellular signaling. Mutations in the B4GALT7 gene are linked to connective tissue disorders like Ehlers-Danlos syndrome (progeroid type) and Larsen syndrome, characterized by joint hypermobility, skin fragility, and skeletal abnormalities.
This antibody is widely used in research to study B4GALT7 expression, localization, and function in tissues or cell lines, employing techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Its specificity for the N-terminal domain ensures recognition of full-length or truncated protein variants, aiding investigations into disease mechanisms or regulatory pathways.
Developed through immunization with synthetic peptides or recombinant protein fragments, the antibody’s performance is typically validated for cross-reactivity, sensitivity, and specificity across species (e.g., human, mouse). Researchers rely on it to explore roles of B4GALT7 in developmental biology, ECM remodeling, and pathologies like cancer or fibrosis, where altered proteoglycan synthesis impacts tissue integrity. Its utility extends to diagnostic research for genetic disorders linked to GAG biosynthesis defects.
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