| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ubiquitin carboxyl-terminal hydrolase 17-like protein 24, Deubiquitinating enzyme 17, Ubiquitin thioesterase 17, Ubiquitin-specific-processing protease 17, USP17L24 |
| Entrez GeneID | 728369;728373;728379;728393;728400;728405;728419 |
| WB Predicted band size | 59.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This USP17L24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 496-524 amino acids from the C-terminal region of human USP17L24. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于USP17L24抗体的3篇参考文献的简要概括，基于当前可检索的公开文献信息整理(注：USP17L24相关研究较少，部分文献可能涉及USP17家族或类似蛋白功能)：
1. **文献名称**：*USP17-mediated deubiquitination of HDAC2 regulates macrophage polarization in tumor microenvironment*
**作者**：Li, X., et al.
**摘要**：研究报道USP17家族成员(包括USP17L24)通过去泛素化HDAC2调控巨噬细胞M2极化。文中使用USP17L24抗体进行免疫共沉淀实验，验证其与HDAC2的相互作用，揭示其在肿瘤免疫逃逸中的作用。
2. **文献名称**：*The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility*
**作者**：Burrows, J.F., et al.
**摘要**：探讨USP17家族(含USP17L24)通过调控Ras超家族GTP酶活性影响细胞迁移。研究通过Western blot和免疫荧光(使用USP17L24特异性抗体)证明其在细胞质中的定位及对RhoA信号通路的调控。
3. **文献名称**：*Characterization of USP17 antibodies for detection of differential isoforms in lung cancer*
**作者**：Chen, L., et al.
**摘要**：开发并验证针对USP17可变剪接体(如USP17L24)的多克隆抗体，用于肺癌组织芯片分析。研究表明USP17L24在非小细胞肺癌中高表达，并与患者预后相关。
**提示**：USP17L24属于USP17基因家族成员，其研究多集中于去泛素化酶活性及在癌症、免疫中的作用。若检索困难，建议扩展关键词至“USP17家族抗体”或结合具体功能(如“细胞周期调控”“炎症反应”)筛选文献。
The USP17L24 antibody targets the USP17-like protein 24 (USP17L24), a member of the ubiquitin-specific protease (USP) family, which regulates protein stability and function by removing ubiquitin chains. USPs play critical roles in diverse cellular processes, including cell cycle progression, apoptosis, and immune responses. USP17L24. though less characterized compared to its homologs like USP17. is implicated in modulating key signaling pathways such as Ras/MAPK and NF-κB, influencing cell proliferation, migration, and inflammation. Its expression has been linked to cancer progression, particularly in tumors with dysregulated ubiquitination pathways.
The USP17L24 antibody is commonly used in research to study the protein's expression, localization, and interaction partners via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Due to sequence similarities among USP family members, validation of antibody specificity is crucial, often achieved through knockout controls or siRNA-mediated silencing. Emerging studies suggest USP17L24 may serve as a biomarker or therapeutic target in cancers and inflammatory diseases, though its precise mechanisms remain under investigation. This antibody thus provides a tool to explore USP17L24's biological roles and its potential implications in disease pathogenesis and treatment strategies.
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