| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein DGCR14, DiGeorge syndrome critical region 13, DiGeorge syndrome critical region 14, DiGeorge syndrome protein H, DGS-H, Protein ES2, DGCR14, DGCR13, DGSH, DGSI, ES2 |
| Entrez GeneID | 8220 |
| WB Predicted band size | 52.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This DGCR14 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 449-482 amino acids from the C-terminal region of human DGCR14. |
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以下是关于DGCR14抗体的3篇示例文献(注：文献为虚构示例，仅用于格式参考)：
1. **"Characterization of DGCR14 Protein Localization Using a Novel Monoclonal Antibody"**
- **作者**: Yamamoto A, et al.
- **摘要**: 研究通过开发一种新型DGCR14单克隆抗体，利用免疫荧光和Western blot技术，揭示了DGCR14在细胞核中的特异性定位，并发现其在细胞周期调控中的潜在作用。
2. **"DGCR14 Interacts with RNA Splicing Factors: Evidence from Co-Immunoprecipitation Studies"**
- **作者**: Chen L, et al.
- **摘要**: 采用DGCR14抗体进行免疫共沉淀实验，证明DGCR14与多种RNA剪接因子(如SF3B1)存在相互作用，提示其参与RNA加工过程的分子机制。
3. **"Altered Expression of DGCR14 in DiGeorge Syndrome Model Mice"**
- **作者**: Müller S, et al.
- **摘要**: 通过免疫组化分析DGCR14抗体在22q11.2缺失综合征小鼠模型中的表达变化，发现DGCR14下调可能与神经发育异常相关。
(提示：实际文献需通过PubMed或Google Scholar检索关键词“DGCR14 antibody”获取。)
The DGCR14 antibody targets the DiGeorge Syndrome Critical Region Gene 14 (DGCR14) protein, encoded by the DGCR14 gene located within the chromosomal region 22q11.2. This genomic region is associated with DiGeorge syndrome, a developmental disorder linked to 22q11.2 deletions. DGCR14 is a conserved, ubiquitously expressed protein implicated in transcriptional regulation, RNA processing, and cell cycle control. Studies suggest its role in modulating chromatin structure, potentially through interactions with histone modifiers or chromatin-remodeling complexes. It has also been linked to ribosome biogenesis and spliceosome assembly, indicating involvement in post-transcriptional gene regulation.
DGCR14 antibodies are widely used in research to investigate the protein's expression, localization, and molecular interactions. In immunofluorescence, they highlight DGCR14's nuclear or nucleolar distribution, while immunoprecipitation studies help identify binding partners. Dysregulation of DGCR14 has been explored in neurodevelopmental disorders and cancers, though its precise mechanistic contributions remain under investigation. Commercial DGCR14 antibodies are typically validated for specificity via knockout cell lines or siRNA knockdown. Researchers utilize these tools to unravel DGCR14's biological functions and its potential as a biomarker or therapeutic target in 22q11.2-related pathologies.
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