Rabbit Polyclonal (DANRE)sdhb Antibody

The SDHB antibody is a crucial tool in biomedical research, specifically targeting the succinate dehydrogenase complex subunit B (SDHB), a key component of mitochondrial complex II involved in both the electron transport chain and the Krebs cycle. SDHB mutations are linked to hereditary paraganglioma/pheochromocytoma syndromes and other cancers, making this antibody vital for diagnosing SDH-deficient tumors and studying mitochondrial dysfunction. In research, the SDHB antibody is used to assess protein expression via techniques like immunohistochemistry (IHC) and Western blot, helping identify loss of SDHB as a marker of SDHx gene mutations. In zebrafish (*Danio rerio*), or "DANRE," this antibody aids in studying developmental biology, metabolic pathways, and disease modeling due to the organism’s genetic tractability and translucency. Zebrafish SDHB shares high homology with human SDHB, enabling cross-species insights into mitochondrial disorders and tumorigenesis. Researchers utilize the antibody to explore gene-editing outcomes, tissue-specific SDHB expression, and responses to metabolic stressors, bridging molecular mechanisms with in vivo physiological contexts. Its application in zebrafish models enhances understanding of SDHB’s role in development, energy metabolism, and cancer, supporting translational research in precision oncology and mitochondrial diseases.