| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ATP-dependent RNA helicase SUPV3L1, mitochondrial, Suppressor of var1 3-like protein 1, SUV3-like protein 1, SUPV3L1, SUV3 |
| Entrez GeneID | 6832 |
| WB Predicted band size | 88.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This SUPV3L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-121 amino acids from the N-terminal region of human SUPV3L1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SUPV3L1 (N-term)抗体的虚构参考文献示例(仅供示例用途，非真实文献)：
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1. **文献名称**：*SUPV3L1 helicase activity and mitochondrial localization revealed by N-terminal specific antibody*
**作者**：Smith A, et al.
**摘要**：本研究利用SUPV3L1 N端特异性抗体，通过免疫荧光和Western blot技术，证实了SUPV3L1在细胞核和线粒体中的双重定位，并揭示其RNA解旋酶活性对线粒体RNA加工的关键作用。
2. **文献名称**：*Development and validation of a monoclonal antibody targeting the N-terminus of SUPV3L1 for cancer biomarker studies*
**作者**：Lee B, et al.
**摘要**：作者开发了一种高特异性SUPV3L1 N端单克隆抗体，验证了其在结直肠癌组织中的高表达，并证明其与肿瘤细胞增殖和迁移的相关性。
3. **文献名称**：*SUPV3L1 interacts with DNA repair machinery: Insights from co-immunoprecipitation using an N-terminal epitope antibody*
**作者**：Johnson C, et al.
**摘要**：通过SUPV3L1 N端抗体的免疫共沉淀实验，发现SUPV3L1与多种DNA损伤修复蛋白(如PARP1)存在相互作用，提示其在基因组稳定性中的新功能。
4. **文献名称**：*Tissue-specific expression profiling of SUPV3L1 using a novel N-terminal antibody panel*
**作者**：Garcia D, et al.
**摘要**：研究利用新型SUPV3L1 N端抗体组，系统分析了其在人类不同组织中的表达差异，发现其在肝脏和脑组织中显著富集，可能与代谢调控相关。
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注：以上内容为模拟生成，实际文献需通过学术数据库(如PubMed、Web of Science)检索。
The SUPV3L1 (N-term) antibody is a tool for detecting the N-terminal region of the SUPV3L1 protein, a member of the Suv3-like RNA helicase family. SUPV3L1. also known as hSuv3 or SUPV3L1. is a nuclear-encoded mitochondrial protein involved in RNA metabolism, including RNA degradation, processing, and surveillance. It plays a critical role in maintaining mitochondrial genome stability and regulating mitochondrial RNA turnover. The protein contains conserved helicase domains and is associated with the mitochondrial degradosome complex, which processes aberrant RNAs and ensures mitochondrial function.
This antibody is commonly used in research to study SUPV3L1's expression, localization, and interactions in cellular models. By targeting the N-terminal region, it helps identify full-length isoforms or cleavage products in applications like Western blotting, immunofluorescence, and immunoprecipitation. Validation often includes testing in SUPV3L1-knockdown or knockout systems to confirm specificity. Dysregulation of SUPV3L1 has been linked to mitochondrial disorders, neurodegenerative diseases, and cancer, making this antibody valuable for exploring its role in pathology. Researchers also utilize it to investigate mitochondrial RNA quality control mechanisms and stress responses. Commercial versions may vary in host species, clonality, or conjugation, but their primary utility lies in elucidating SUPV3L1's contributions to cellular homeostasis and disease pathways.
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