| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ephrin type-A receptor 10, EPHA10 |
| Entrez GeneID | 284656 |
| WB Predicted band size | 109.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This EPHA10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-179 amino acids from the N-terminal region of human EPHA10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于EPHA10 (N-term)抗体的示例参考文献(注：部分为假设性文献，实际文献需通过学术数据库验证)：
1. **"EPHA10 receptor tyrosine kinase is overexpressed in breast cancer and promotes tumor progression"**
- **作者**: Smith J, et al. (2018)
- **摘要**: 本研究开发了一种针对EPHA10 N端的特异性抗体，用于检测乳腺癌组织中EPHA10的表达水平。结果显示，EPHA10在肿瘤组织中显著高表达，且与其促进细胞迁移和侵袭的能力相关。
2. **"Targeting EPHA10 with a novel N-terminal antibody inhibits prostate cancer cell proliferation"**
- **作者**: Zhang L, et al. (2020)
- **摘要**: 文章报道了一种针对EPHA10 N端结构域的单克隆抗体，通过阻断受体二聚化抑制前列腺癌细胞增殖，并在小鼠模型中验证了其抗肿瘤效果。
3. **"EPHA10 as a diagnostic biomarker in gastrointestinal cancers: validation of an N-terminal antibody for immunohistochemistry"**
- **作者**: Lee S, et al. (2019)
- **摘要**: 研究利用EPHA10 (N-term)抗体对胃癌和结直肠癌组织进行免疫组化分析，证实该抗体具有高特异性，且EPHA10表达与患者预后不良相关。
4. **"Characterization of EPHA10 signaling pathways in pancreatic cancer using a domain-specific antibody"**
- **作者**: Patel R, et al. (2021)
- **摘要**: 通过EPHA10 N端抗体研究其在胰腺癌中的下游信号通路，发现EPHA10通过激活MAPK/ERK通路促进肿瘤生长，抗体阻断可显著减少肿瘤侵袭。
**建议**：以上为示例，实际文献请通过PubMed、Google Scholar等平台检索关键词(如“EPHA10 antibody N-terminal”)获取，并优先选择近5年内的研究以反映最新进展。
The EPHA10 (N-term) antibody is a monoclonal or polyclonal antibody specifically designed to target the N-terminal region of the Ephrin type-A receptor 10 (EPHA10), a member of the Eph receptor tyrosine kinase family. Eph receptors are critical regulators of cell-cell communication, playing roles in developmental processes, tissue patterning, and cancer progression. EPHA10. primarily expressed in reproductive tissues like the testis and prostate, has garnered interest for its potential involvement in cell adhesion, migration, and oncogenic signaling. Unlike other Eph receptors, EPHA10 exhibits unique structural features, including a truncated cytoplasmic domain lacking canonical kinase activity, suggesting non-enzymatic or adaptive signaling functions.
The N-terminal region of EPHA10 contains the ligand-binding domain, which mediates interactions with ephrin-A ligands. Antibodies targeting this region are often used to study receptor localization, expression levels, and ligand-receptor interactions in physiological and pathological contexts. Researchers employ EPHA10 (N-term) antibodies in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate its role in cancers, including prostate and breast cancer, where aberrant EPHA10 expression correlates with tumor progression and metastasis. Additionally, these antibodies aid in exploring EPHA10's potential as a therapeutic target or diagnostic biomarker. Validation of specificity through knockout controls or peptide blocking assays is essential to ensure reliable experimental outcomes.
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