| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein HMX2, Homeobox protein Nkx-52, Hmx2, Nkx-52, Nkx5-2 |
| Entrez GeneID | 15372 |
| WB Predicted band size | 29.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This HMX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-180 amino acids of mouse HMX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HMX2抗体的3篇参考文献及其摘要概括：
1. **文献名称**: "HMX2 regulates epithelial cell cycle progression and corneal morphogenesis"
**作者**: Smith J, et al.
**摘要**: 研究利用HMX2抗体在小鼠模型中揭示HMX2在角膜上皮细胞周期调控中的作用，发现其通过调控Cyclin D1表达影响发育过程中的细胞增殖。
2. **文献名称**: "The role of HMX2 in neural crest-derived craniofacial development"
**作者**: Lee S, et al.
**摘要**: 通过免疫组化(使用HMX2抗体)和基因敲除技术，证明HMX2在颅面神经嵴细胞迁移和骨骼形成中起关键作用，缺失导致小鼠颅骨发育异常。
3. **文献名称**: "HMX2 antibody validation for human retinal studies"
**作者**: Garcia R, et al.
**摘要**: 该文献系统验证了HMX2抗体在人视网膜组织中的特异性，确认其适用于Western blot和免疫荧光，并发现HMX2在成年视网膜中的持续表达可能与光感受器维持相关。
*注：HMX2相关研究相对较少，上述内容为模拟概括，实际文献需通过学术数据库(如PubMed)检索确认。*
HMX2 (H6 family homeobox 2) is a transcription factor encoded by the *HMX2* gene, belonging to the homeobox gene family characterized by a conserved 60-amino acid DNA-binding domain. It plays critical roles in embryonic development, particularly in the formation of sensory organs and craniofacial structures. Studies have shown that HMX2 is essential for the development of the inner ear, eyes, and parts of the nervous system, regulating cell differentiation and tissue patterning through interactions with specific genetic pathways. Dysregulation of HMX2 has been linked to congenital defects, though its full mechanistic role remains under investigation.
HMX2 antibodies are immunological tools designed to detect and quantify HMX2 protein expression in research settings. These antibodies are typically produced in hosts like rabbits or mice using immunogenic peptides derived from conserved regions of the HMX2 protein. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study HMX2's spatial-temporal expression patterns during development or disease. Validated HMX2 antibodies demonstrate specificity through controls like knockout cell lines or tissues. Researchers employ these antibodies to explore HMX2's involvement in developmental disorders, neural crest cell migration, and potential roles in cancer or regenerative processes. Commercial HMX2 antibodies often come with validation data for cross-reactivity and batch consistency.
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