Rabbit Polyclonal (Mouse)Wdr5 Antibody

The Wdr5 (WD repeat-containing protein 5) antibody is a critical tool for studying the role of Wdr5 in chromatin remodeling and epigenetic regulation. Wdr5 is a conserved nuclear protein that serves as a core subunit of multiple histone-modifying complexes, including the MLL/SET1 family of histone H3 lysine 4 (H3K4) methyltransferases. It facilitates the assembly of these complexes and directly interacts with histone H3. aiding in the recognition of unmethylated histone H3K4 to promote transcriptional activation. Mouse Wdr5 shares high homology with human WDR5. making it a common model for studying its functions in development, stem cell biology, and cancer. Antibodies targeting mouse Wdr5 are widely used in techniques such as chromatin immunoprecipitation (ChIP), immunofluorescence (IF), and Western blotting to investigate its localization, protein-protein interactions, and involvement in gene expression regulation. These antibodies are typically raised against specific epitopes or recombinant protein fragments of mouse Wdr5 and validated for specificity through knockout controls or siRNA knockdown experiments. Their applications extend to exploring Wdr5's role in diseases linked to epigenetic dysregulation, such as leukemia or developmental disorders, where aberrant H3K4 methylation patterns are observed. Reliable Wdr5 antibodies are essential for dissecting molecular mechanisms underlying chromatin dynamics and transcriptional control.