| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/25 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Actin-like protein 6A, 53 kDa BRG1-associated factor A, Actin-related protein Baf53a, BRG1-associated factor 53A, BAF53A, Actl6a, Actl6, Baf53a |
| Entrez GeneID | 56456 |
| WB Predicted band size | 47.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Actl6a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 295-320 amino acids from the C-terminal region of Mouse Actl6a. |
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以下是关于Mouse Actl6a抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用需核实)：
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1. **文献名称**: "Actl6a maintains embryonic stem cell self-renewal through regulation of the BAF complex"
**作者**: Smith J, et al.
**摘要**: 本研究利用Mouse Actl6a特异性抗体，通过免疫沉淀和ChIP-seq技术，揭示了Actl6a在BAF复合物中调控胚胎干细胞多能性基因(如Oct4、Nanog)表达的作用机制。实验表明，Actl6a缺失导致BAF复合物稳定性下降，进而影响干细胞自我更新能力。
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2. **文献名称**: "Actl6a-dependent chromatin remodeling in neural progenitor differentiation"
**作者**: Li X, et al.
**摘要**: 该研究通过Western blot和免疫荧光技术，使用Mouse Actl6a抗体证实了其在神经前体细胞分化中的关键作用。结果显示，Actl6a通过调控Sox2等神经发育相关基因的染色质可及性，影响神经元分化进程。
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3. **文献名称**: "Oncogenic role of Actl6a in lung adenocarcinoma via BAF complex-mediated transcriptional dysregulation"
**作者**: Wang Y, et al.
**摘要**: 本文利用Mouse Actl6a抗体在肺癌小鼠模型中验证了其过表达与肿瘤进展的关系。研究发现，Actl6a通过BAF复合物异常激活致癌通路(如MYC)，并可作为潜在治疗靶点。
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(注：以上文献为示例性质，实际研究中请根据具体实验需求检索并引用真实文献。)
**Background of Mouse ACTL6A Antibody**
ACTL6A (Actin-like 6A), also known as BAF53A, is a subunit of chromatin-remodeling complexes such as the BAF (BRG1/BRM-associated factor) complex, which regulates gene expression by modulating chromatin structure. It belongs to the evolutionarily conserved actin-related protein (Arp) family and plays critical roles in embryonic development, cell differentiation, and oncogenesis. ACTL6A is essential for maintaining the stability of the BAF complex and its ability to interact with nuclear actin, facilitating transcriptional regulation and DNA repair.
Mouse ACTL6A antibodies are widely used to study the protein's expression, localization, and function in murine models. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Research highlights its involvement in neural development, stem cell pluripotency, and cancer, where aberrant ACTL6A expression correlates with tumor progression (e.g., squamous cell carcinoma, glioblastoma). The antibody is also valuable in exploring epigenetic mechanisms, as ACTL6A-containing complexes mediate histone modification and chromatin dynamics.
Validated antibodies typically target specific epitopes, ensuring specificity for murine ACTL6A. Their application aids in dissecting molecular pathways in development and disease, making them crucial tools in epigenetics and oncology research.
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