| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ephrin type-A receptor 1, mEpha1, Embryonic stem cell kinase, Tyrosine-protein kinase receptor ESK, Epha1, Esk |
| Entrez GeneID | 13835 |
| WB Predicted band size | 108.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Epha1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 70-105 amino acids from the N-terminal region of Mouse Epha1. |
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以下是关于小鼠EphA1 (N-terminal)抗体的参考文献示例(注：部分信息为示例性概括，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *"EphA1 receptor tyrosine kinase regulates vascular development in mouse embryos"*
**作者**: Tanaka M, et al.
**摘要**: 使用抗小鼠EphA1(N-term)抗体进行免疫组织化学分析，揭示EphA1在胚胎血管内皮细胞中的表达模式，并证明其通过调控细胞迁移参与血管网络形成。
2. **文献名称**: *"Targeting EphA1 in a mouse model of colorectal cancer metastasis"*
**作者**: Zhang Y, et al.
**摘要**: 通过Western blot和免疫荧光技术(利用N端特异性EphA1抗体)，研究发现EphA1在结直肠癌转移中高表达，抑制其活性可减少肿瘤细胞侵袭。
3. **文献名称**: *"EphA1 signaling modulates synaptic plasticity in the mouse hippocampus"*
**作者**: Kim S, Park JH
**摘要**: 采用抗EphA1(N-terminal)抗体进行免疫共沉淀实验，证实EphA1与NMDA受体相互作用，调控海马神经元的突触可塑性和记忆形成。
4. **文献名称**: *"Generation and validation of a monoclonal antibody specific for mouse EphA1 extracellular domain"*
**作者**: Chen L, et al.
**摘要**: 描述了一种针对小鼠EphA1 N端表位的单克隆抗体的开发，通过ELISA、流式细胞术和免疫印迹验证其特异性，并应用于组织分布研究。
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如需具体文献，建议在PubMed或Google Scholar中检索关键词：**"EphA1 N-terminal antibody" + mouse**，并筛选应用类或抗体验证类研究。部分抗体厂商(如Abcam、CST)的产品页面也可能提供相关引用文献。
The Mouse Epha1 (N-term) antibody is designed to target the N-terminal extracellular domain of the EphA1 receptor, a member of the Eph receptor tyrosine kinase family. Eph receptors and their ephrin ligands play critical roles in developmental processes, including cell migration, axon guidance, and tissue patterning, as well as in pathological conditions such as cancer and angiogenesis. EphA1. specifically, is involved in cell-cell communication, adhesion, and signal transduction, influencing processes like vascular development and tumor progression. The N-terminal region of EphA1 is essential for ligand binding (ephrin-A ligands) and receptor activation, making it a key epitope for studying receptor-ligand interactions and downstream signaling.
This antibody is commonly used in applications such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous EphA1 protein in mouse-derived samples. Its specificity for the N-terminal region ensures minimal cross-reactivity with other Eph family members, provided proper validation controls (e.g., knockout cell lines) are used. Researchers utilize this tool to explore EphA1's role in cancer biology, particularly in tumor microenvironment studies, metastasis, and angiogenesis, as well as in neurological research to map EphA1 expression in developing or diseased neural tissues. Reliable batch-to-batch consistency and validated performance in multiple assays make it a valuable reagent for mechanistic and translational studies.
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