Rabbit Polyclonal NDUFV3 Antibody

The NDUFV3 antibody is a specialized tool used to detect the NADH:ubiquinone oxidoreductase core subunit V3 (NDUFV3), a critical component of mitochondrial Complex I (NADH dehydrogenase) in the electron transport chain. Complex I facilitates the transfer of electrons from NADH to ubiquinone, driving proton translocation and ATP production. NDUFV3. encoded by the *NDUFV3* gene, is one of several flavoprotein subunits within the matrix arm of Complex I, contributing to its structural integrity and catalytic activity. Dysfunction in Complex I subunits, including NDUFV3. is linked to mitochondrial disorders, neurodegenerative diseases (e.g., Parkinson’s disease), and metabolic conditions due to disrupted oxidative phosphorylation and elevated reactive oxygen species (ROS). Researchers employ NDUFV3 antibodies in techniques like Western blotting, immunohistochemistry, or immunofluorescence to study protein expression, subcellular localization, and mitochondrial health in disease models. These antibodies also aid in identifying mutations or deficiencies in NDUFV3 associated with clinical phenotypes, offering insights into disease mechanisms or therapeutic targets. Specificity and validation (e.g., knockout controls) are essential to ensure accurate detection, given the structural similarities among Complex I subunits.