Rabbit Polyclonal IZUMO2 Antibody

The IZUMO2 antibody is a research tool developed to study the IZUMO2 protein, a key player in mammalian fertilization. Discovered as part of the IZUMO family (IZUMO1-4), these proteins are critical for sperm-egg membrane fusion. While IZUMO1. identified in 2005. is the most characterized and essential for fertilization, IZUMO2 was later found to play a supportive role. Both proteins localize to the sperm surface and undergo dynamic redistribution during capacitation. IZUMO2 antibodies are primarily used to investigate its interaction with IZUMO1 and its compensatory mechanisms in fertilization. Studies using these antibodies in knockout models suggest that IZUMO2 partially rescues fertility in IZUMO1-deficient mice, highlighting functional redundancy. Researchers employ IZUMO2 antibodies in Western blotting, immunofluorescence, and functional assays to explore sperm maturation, acrosome reaction, and species-specific fusion mechanisms. These tools also contribute to contraceptive development and infertility research, as disrupted IZUMO interactions impair gamete fusion. Recent work focuses on structural analysis of IZUMO2-JUNO receptor interactions, informing both reproductive biology and protein engineering applications.