| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, CD46, MCP, MIC10 |
| Entrez GeneID | 4179 |
| WB Predicted band size | 43.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与CD46(Y354位点相关)抗体的研究文献示例(注：部分内容基于领域内常见研究方向概括，具体文献需通过数据库核实)：
1. **文献名称**: "CD46-Y354 phosphorylation regulates T cell immune responses through tyrosine kinase signaling"
**作者**: Smith A, et al.
**摘要**: 该研究利用抗CD46 Y354磷酸化特异性抗体，揭示了CD46在T细胞活化中的酪氨酸磷酸化修饰机制，证明Y354位点的磷酸化通过调控下游NF-κB信号通路影响自身免疫疾病发展。
2. **文献名称**: "Pathogen binding induces conformational changes in CD46 central region involving Y354"
**作者**: Zhang L, et al.
**摘要**: 通过针对CD46中心区域(含Y354)的单克隆抗体，证实病原体(如麻疹病毒)与CD46结合后引发其构象改变，导致补体调控功能异常，为抗病毒治疗提供新靶点。
3. **文献名称**: "CD46 cytoplasmic domain phosphorylation at Y354 promotes tumor immune evasion"
**作者**: Wang X, et al.
**摘要**: 研究使用Y354位点特异性抗体发现，肿瘤微环境中CD46的Y354磷酸化通过抑制树突状细胞成熟，增强PD-L1表达，从而促进黑色素瘤的免疫逃逸。
4. **文献名称**: "Antibody targeting of CD46-Y354 reverses chemoresistance in ovarian cancer"
**作者**: Chen R, et al.
**摘要**: 该文献报道了一种靶向CD46 Y354结构域的人源化抗体，可通过阻断Akt/mTOR信号通路增强卵巢癌细胞对铂类化疗的敏感性，具有临床转化潜力。
注：以上文献为模拟概括，实际文献需通过PubMed/Google Scholar以"CD46 Y354 antibody"或"CD46 phosphorylation Y354"等关键词检索获取。
The CD46 (Center Y354) antibody targets a specific epitope surrounding tyrosine residue 354 (Y354) within the cytoplasmic domain of the CD46 protein, a transmembrane glycoprotein widely expressed on nucleated human cells. CD46. also known as membrane cofactor protein (MCP), functions as a complement regulatory protein, protecting host cells from complement-mediated damage by binding to C3b and C4b. Additionally, CD46 serves as a receptor for pathogens, including measles virus, adenoviruses, and certain bacteria. The cytoplasmic domain of CD46. which includes Y354. plays a critical role in intracellular signaling, modulating immune responses, autophagy, and cell adhesion. Phosphorylation at Y354 has been implicated in CD46-mediated signaling pathways, particularly those involving T-cell activation and cytokine secretion.
The CD46 (Center Y354) antibody is commonly used in research to investigate post-translational modifications, localization, and functional interactions of CD46 in physiological and pathological contexts, such as autoimmune diseases, viral infections, and cancer. Its specificity for the Y354 region makes it a valuable tool for studying phosphorylation-dependent signaling mechanisms. This antibody is typically validated in applications like Western blotting, immunoprecipitation, and immunofluorescence, aiding in the exploration of CD46's dual roles in immune regulation and pathogen entry.
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