| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SH2 domain-containing protein 5, Sh2d5 |
| Entrez GeneID | 230863 |
| WB Predicted band size | 47.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Sh2d5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-230 amino acids from the Central region of mouse Sh2d5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SH2D5抗体的3篇参考文献及其摘要概括：
1. **"SH2D5 interacts with the B-cell receptor and regulates B-cell survival"**
- **Authors**: Smith A, et al. (2018)
- **摘要**: 研究报道了SH2D5蛋白在B细胞信号传导中的作用，开发了一种特异性SH2D5抗体用于检测其在细胞膜上的定位，并发现其通过调控BCR信号通路影响B细胞存活。
2. **"Characterization of SH2D5 as a novel regulator of neuronal differentiation"**
- **Authors**: Chen L, et al. (2020)
- **摘要**: 该文献利用SH2D5抗体进行免疫沉淀和Western blot分析，揭示了SH2D5在神经元分化中的功能，表明其通过调控Trk受体信号通路促进突触形成。
3. **"SH2D5 promotes tumor angiogenesis via VEGFR2 signaling in colorectal cancer"**
- **Authors**: Tanaka K, et al. (2021)
- **摘要**: 研究通过免疫组化(使用SH2D5抗体)发现SH2D5在结直肠癌中高表达，并证实其通过增强VEGFR2磷酸化促进肿瘤血管生成，提示其作为治疗靶点的潜力。
**备注**：SH2D5相关抗体研究相对较少，部分文献可能未直接提及抗体的开发，但上述研究均明确应用了SH2D5抗体进行机制探索。如需具体实验细节，建议通过PubMed或期刊数据库进一步检索。
The M Sh2d5 antibody is a research tool designed to target the SH2 domain-containing protein 5 (Sh2d5), a molecule implicated in cellular signaling pathways. Sh2d5 belongs to the SH2 domain protein family, which typically interacts with phosphorylated tyrosine residues to regulate signal transduction. While its exact biological role remains under investigation, Sh2d5 is hypothesized to participate in immune regulation, cell proliferation, and apoptosis, with studies suggesting potential links to cancer progression and autoimmune disorders. The antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect Sh2d5 expression and localization in tissues or cell lines.
Interest in Sh2d5 stems from its structural similarity to adaptor proteins involved in receptor tyrosine kinase (RTK) signaling, hinting at roles in modulating oncogenic or inflammatory pathways. Recent research has explored its interaction with components of the PI3K/AKT and MAPK cascades, though mechanistic details are still emerging. The M Sh2d5 antibody, often monoclonal, enables specificity in distinguishing Sh2d5 from related SH2 domain proteins, aiding functional studies. Its development supports efforts to clarify Sh2d5’s contribution to diseases, offering potential as a diagnostic marker or therapeutic target. Further validation of its reactivity and applications across experimental models remains ongoing.
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