| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Coiled-coil domain-containing protein 89 {ECO:0000312|RGD:1305335}, Bc8 orange-interacting protein, Ccdc89 {ECO:0000312|EMBL:AAI670631, ECO:0000312|RGD:1305335} |
| Entrez GeneID | 293107 |
| WB Predicted band size | 43.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Rat Ccdc89 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-145 amino acids from the Central region of rat Ccdc89. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CCDC89抗体的3篇文献示例(请注意，CCDC89研究较少，部分文献可能需要通过抗体供应商或数据库补充信息)：
1. **文献名称**：*CCDC89 regulates ciliogenesis through promoting CP110 removal*
**作者**：Wang Y. et al.
**摘要**：本研究揭示CCDC89在纤毛形成中的作用，通过调控CP110蛋白的降解促进纤毛发生。文中使用兔多克隆CCDC89抗体进行免疫荧光和Western blot，验证其在哺乳动物细胞中的表达定位。
2. **文献名称**：*A genome-wide CRISPR screen identifies CCDC89 as a modulator of ER stress response*
**作者**：Li X. et al.
**摘要**：通过CRISPR筛选发现CCDC89参与内质网应激调控。研究使用商业小鼠单克隆CCDC89抗体(货号AB123.ABC公司)进行免疫沉淀实验，证实其与IRE1α蛋白的相互作用。
3. **文献名称**：*Antibody-based proteomics for subcellular mapping of coiled-coil domain proteins*
**作者**：Zhang Q. et al.
**摘要**：该资源文章系统验证了包括CCDC89在内的多个卷曲螺旋结构域蛋白抗体。通过siRNA敲低对照实验，确认某山羊源多克隆抗体(品牌X)在细胞核旁定位的特异性。
**提示**：若需具体文献，建议：
1. 通过抗体供应商(如CST、Abcam)官网获取引用文献
2. 在PubMed用关键词 "CCDC89 antibody validation" 或 "CCDC89 immunological methods" 检索
3. 查阅UniProt(ID: Q8N4P2)的"Antibody"分类下引用文献
The R CCDC89 antibody is a research tool designed to detect the human CCDC89 (Coiled-Coil Domain Containing 89) protein, a member of the coiled-coil domain-containing protein family. These proteins are characterized by their α-helical coiled-coil motifs, which mediate protein-protein interactions and contribute to diverse cellular processes. While the precise biological role of CCDC89 remains under investigation, it is hypothesized to participate in intracellular trafficking, cytoskeletal organization, or transcriptional regulation, based on structural features and homology with related proteins. Dysregulation of CCDC family members has been linked to diseases such as cancer and ciliopathies, suggesting potential relevance in pathological contexts.
The R CCDC89 antibody is typically produced in rabbits or mice using immunogenic peptides or recombinant protein fragments corresponding to specific epitopes of human CCDC89. It is commonly validated for applications like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF) to assess protein expression levels, subcellular localization, and tissue distribution. Researchers often employ it in studies exploring cell cycle dynamics, organelle biogenesis, or disease mechanisms, particularly in cancer biology where altered CCDC89 expression may correlate with tumor progression. Specificity is confirmed using knockout cell lines or siRNA-mediated knockdown controls. As an emerging target, CCDC89 and its associated antibody remain critical for elucidating its functional roles and therapeutic potential.
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