| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nuclear pore complex-interacting protein family member B15, Nuclear pore complex-interacting protein-like 2, NPIPB15, NPIPL2 |
| Entrez GeneID | 440348 |
| WB Predicted band size | 51.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NPIPL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the C-terminal region of human NPIPL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于假设的3-4篇关于NPIPL2抗体的参考文献示例(注：以下内容可能为虚构，实际文献需通过学术数据库核实)：
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1. **文献名称**：*Development of a Polyclonal Antibody Against NPIPL2 for Analysis of Autophagy Regulation*
**作者**：Chen X, Wang Y, et al.
**摘要**：研究团队开发了一种针对NPIPL2蛋白的多克隆抗体，验证了其在Western blot和免疫荧光中的特异性，并发现NPIPL2通过调控自噬相关蛋白LC3-II的表达参与细胞应激反应。
2. **文献名称**：*NPIPL2 Antibody Application in Detecting Nuclear Pore Complex Abnormalities*
**作者**：Müller S, et al.
**摘要**：利用新制备的小鼠源单克隆抗体，揭示了NPIPL2在核孔复合体组装缺陷细胞模型中的异常定位，提示其与遗传性核膜疾病的潜在关联。
3. **文献名称**：*A Novel Anti-NPIPL2 Monoclonal Antibody for Cancer Biomarker Screening*
**作者**：Ito H, et al.
**摘要**：通过抗NPIPL2抗体的高通量免疫组化分析，发现该蛋白在结直肠癌组织中的高表达与患者预后不良显著相关，可能成为新型诊断标志物。
4. **文献名称**：*NPIPL2 Knockout Validation Using CRISPR/Cas9 and Antibody-Based Protein Profiling*
**作者**：Gupta R, et al.
**摘要**：研究结合CRISPR/Cas9基因编辑和抗NPIPL2抗体验证，证实了NPIPL2缺失导致细胞周期阻滞，并提供了该抗体在功能性研究中的可靠性数据。
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**建议**：若需真实文献，请通过PubMed或Google Scholar检索关键词(如“NPIPL2 antibody”或“NPIPL2 protein function”)，并核实目标蛋白的标准命名(可能存在拼写变异，例如NUPIP或NPIPB2等)。
The NPIPL2 (Nuclear Pore Complex Interacting Protein Like 2) antibody is a research tool designed to detect and study the NPIPL2 protein, a member of the NPIP family. This family is characterized by proteins interacting with nuclear pore complex (NPC) components, which regulate nucleocytoplasmic transport. NPIPL2 shares homology with other NPIP members, containing conserved domains implicated in protein-protein interactions, though its precise molecular function remains under investigation. Genomic studies suggest NPIPL2 may play roles in cellular processes such as DNA repair, transcriptional regulation, or cell cycle control, potentially linked to its nuclear localization.
The antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze NPIPL2 expression patterns, subcellular localization, and abundance across tissues or experimental conditions. Its development often involves immunizing hosts with synthetic peptides or recombinant protein fragments unique to NPIPL2. followed by affinity purification to ensure specificity.
Interest in NPIPL2 stems from its potential involvement in diseases. Some studies associate NPIPL2 dysregulation with cancer progression or neurological disorders, though mechanistic insights are limited. Researchers utilize this antibody to explore NPIPL2's interactions with NPC components, its response to cellular stressors, or its expression changes in disease models. Validation steps, including knockout controls and cross-reactivity tests, are critical to confirm antibody reliability. Ongoing research aims to clarify NPIPL2's biological significance and therapeutic relevance.
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