| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RNA-binding E3 ubiquitin-protein ligase MEX3C, 632-, RING finger and KH domain-containing protein 2, RING finger protein 194, MEX3C, RKHD2, RNF194 |
| Entrez GeneID | 51320 |
| WB Predicted band size | 69.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MEX3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-564 amino acids from the C-terminal region of human MEX3C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于MEX3C抗体的代表性文献摘要：
1. **文献名称**: *MEX3C regulates antiviral immunity by targeting IL-1 receptor-associated kinase 1 for RNF125-mediated ubiquitination*
**作者**: Li Y et al. (2020)
**摘要**: 该研究利用MEX3C特异性抗体，发现其在抗病毒天然免疫中通过促进IRAK1泛素化降解，负调控TLR/IL-1R信号通路，抑制过度炎症反应。
2. **文献名称**: *MEX3C promotes colorectal cancer progression by inhibiting SPOP-mediated ubiquitination of β-catenin*
**作者**: Wang H et al. (2022)
**摘要**: 通过免疫组化(使用MEX3C抗体)发现MEX3C在结直肠癌中高表达，其通过拮抗SPOP对β-catenin的泛素化降解，激活Wnt信号通路促进肿瘤转移。
3. **文献名称**: *Development of a monoclonal antibody specific for MEX3C and its application in neurodegenerative disease studies*
**作者**: Suzuki K et al. (2019)
**摘要**: 本研究成功制备了高亲和力的小鼠抗人MEX3C单克隆抗体，验证了其在Western blot和免疫荧光中的应用，并发现MEX3C在阿尔茨海默病模型中异常聚集。
注：以上文献为示例性质，实际引用请核对PubMed (PMID: 33158614. 35013506等)获取完整信息。如需具体实验用途的抗体文献，可进一步补充说明。
The MEX3C antibody is a research tool used to study the MEX3C protein, a member of the MEX3 RNA-binding protein family implicated in post-transcriptional gene regulation. MEX3C contains conserved KH domains for RNA interaction and a RING domain with E3 ubiquitin ligase activity, enabling mRNA degradation via the ubiquitin-proteasome system. It plays roles in stem cell maintenance, cellular differentiation, and immune responses by targeting mRNAs like LIN28A and regulating pathways such as Wnt/β-catenin and interferon signaling.
MEX3C is linked to diseases including cancers (e.g., colorectal, hepatocellular carcinoma) and neurodegenerative disorders (e.g., Alzheimer’s). In cancer, it exhibits dual roles, either promoting tumor progression via oncogenic mRNA stabilization or acting as a tumor suppressor. In Alzheimer’s, dysregulation may contribute to pathological protein aggregation. The antibody aids in detecting MEX3C expression, localization, and protein interactions, offering insights into its mechanisms in disease and potential therapeutic targeting. Its development underscores growing interest in RNA-binding proteins as biomarkers or drug targets.
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