| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leucine-rich repeat and calponin homology domain-containing protein 1, Calponin homology domain-containing protein 1, Neuronal protein 81, NP81, LRCH1, CHDC1, KIAA1016 |
| Entrez GeneID | 23143 |
| WB Predicted band size | 80.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LRCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the Central region of human LRCH1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与LRCH1抗体相关的文献摘要概括(注：文献信息为模拟示例，具体研究请以实际数据库检索为准)：
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1. **文献名称**：*LRCH1 regulates neutrophil migration and basement membranebreaching in vivo*
**作者**：Smith A, et al.
**摘要**：本研究利用抗LRCH1抗体通过免疫荧光技术，发现LRCH1蛋白通过调控细胞骨架重组抑制中性粒细胞的迁移能力，并揭示其在炎症反应中的潜在作用机制。
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2. **文献名称**：*LRCH1 suppresses melanoma progression by modulating integrin signaling*
**作者**：Chen L, et al.
**摘要**：通过Western blot和免疫组化(使用LRCH1特异性抗体)，作者发现LRCH1在黑色素瘤中低表达，其缺失通过整合素信号通路促进肿瘤侵袭，提示LRCH1作为抑癌基因的可能性。
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3. **文献名称**：*A novel monoclonal antibody against LRCH1 for flow cytometry analysis*
**作者**：Wang Y, et al.
**摘要**：该研究开发了一种针对LRCH1的新型单克隆抗体，验证了其在流式细胞术中的高特异性，并成功应用于检测T细胞亚群中LRCH1的动态表达变化。
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如需获取真实文献，建议通过PubMed或Google Scholar以关键词“LRCH1 antibody”或“LRCH1 immune function”检索近年研究。
LRCH1 (Leucine-Rich Repeat and Calponin Homology Domain-Containing Protein 1) is a relatively understudied protein encoded by the *LRCH1* gene. It belongs to the LRCH family, characterized by leucine-rich repeats (LRRs) and a calponin homology (CH) domain, suggesting roles in protein-protein interactions and cytoskeletal organization. LRRs are often involved in ligand recognition and signal transduction, while CH domains typically bind actin, implicating LRCH1 in cellular processes like adhesion, migration, or structural maintenance. Limited studies link LRCH1 to immune regulation and cancer. For example, it may modulate T-cell receptor signaling by interacting with kinases like ZAP-70. potentially influencing immune responses. In cancer, altered *LRCH1* expression has been observed in malignancies such as breast and colorectal cancer, though its mechanistic role remains unclear.
LRCH1 antibodies are primarily used as research tools to investigate the protein's expression, localization, and function. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercial antibodies are often validated for specificity in human or mouse models. Challenges include limited validation data due to the protein's low abundance and scarce literature. Recent interest in LRCH1 has grown with advances in proteomics and genomic screens, highlighting its potential involvement in signaling pathways (e.g., Wnt/β-catenin) and diseases like neurodegeneration. Further studies are needed to define its precise biological roles and therapeutic relevance.
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