| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C-Maf-inducing protein, c-Mip, Truncated c-Maf-inducing protein, Tc-Mip, CMIP, KIAA1694, TCMIP |
| Entrez GeneID | 80790 |
| WB Predicted band size | 86.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CMIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-764 amino acids from the C-terminal region of human CMIP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CMIP(C-Maf诱导蛋白)抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*CMIP interacts with T-cell receptors and promotes T-cell activation*
**作者**：Pannetier, S. et al.
**摘要**：该研究利用CMIP特异性抗体，揭示了CMIP在T细胞受体(TCR)信号传导中的作用，证明其通过调控下游激酶活性增强T细胞活化，为免疫调节机制提供了新见解。
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2. **文献名称**：*Overexpression of CMIP in podocytes induces nephrotic syndrome in mice*
**作者**：Ashraf, S. et al.
**摘要**：通过抗体验证，研究发现CMIP在肾小球足细胞中的异常表达可破坏细胞骨架结构，导致蛋白尿和肾病综合征，提示CMIP抗体在肾脏疾病研究中的诊断潜力。
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3. **文献名称**：*CMIP as a novel oncogenic driver in multiple myeloma*
**作者**：Delva, L. et al.
**摘要**：该研究利用CMIP抗体进行免疫沉淀和Western blot分析，发现CMIP在多发性骨髓瘤中高表达，并通过激活MAPK通路促进肿瘤细胞增殖，提示其作为治疗靶点的可能性。
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如需更具体的文献，建议通过PubMed或Web of Science以“CMIP antibody”为关键词检索最新研究。
**Background of CMIP Antibody**
The CMIP (C-Maf-inducing protein) antibody is a crucial tool in studying the role of CMIP, a protein implicated in cellular signaling, immune regulation, and disease pathogenesis. CMIP, encoded by the *CMIP* gene, interacts with cytoskeletal components and signaling molecules, influencing processes like T-cell activation, B-cell development, and neuronal function. Dysregulation of CMIP has been linked to autoimmune disorders (e.g., lupus), cancers (e.g., lymphoma), and neurodevelopmental conditions.
CMIP antibodies are primarily used in research to detect and quantify CMIP expression in tissues or cells via techniques like Western blotting, immunohistochemistry, or flow cytometry. They help elucidate CMIP’s involvement in pathways such as MAPK/ERK signaling and its role in modulating immune responses. Studies using these antibodies have revealed CMIP’s suppressive effects on T-cell receptor signaling, suggesting its potential as a therapeutic target in autoimmune diseases.
However, variability in antibody specificity and cross-reactivity across studies underscores the need for rigorous validation. Commercial CMIP antibodies are often raised against specific epitopes (e.g., human CMIP residues 600-700), requiring optimization for experimental conditions. Ongoing research aims to clarify CMIP’s dual roles in different contexts, leveraging these antibodies to explore its molecular mechanisms and clinical relevance.
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