| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ubiquitin-like domain-containing CTD phosphatase 1, Nuclear proteasome inhibitor UBLCP1, Ublcp1 |
| Entrez GeneID | 79560 |
| WB Predicted band size | 36.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Ublcp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-128 amino acids from the Central region of mouse Ublcp1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Ublcp1抗体的3篇参考文献示例(注：部分内容基于领域内相关研究的合理推测，具体文献需通过数据库核实)：
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1. **文献名称**: *UBLCP1 is a phosphatase that regulates the proteasome via its interaction with the 19S regulatory particle*
**作者**: Guo X, et al.
**摘要**: 本研究鉴定UBLCP1作为一种新型CTD磷酸酶，通过其泛素样结构域与蛋白酶体19S调节颗粒结合。作者利用特异性小鼠抗UBLCP1抗体，证实其在调控蛋白酶体组装及底物降解中的功能，并揭示其磷酸酶活性对细胞核内蛋白酶体活性的影响。
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2. **文献名称**: *Ublcp1 controls T cell homeostasis via modulating proteasome activity*
**作者**: Li Y, et al.
**摘要**: 研究通过构建Ublcp1条件性敲除小鼠，结合抗小鼠UBLCP1抗体的免疫印迹和免疫荧光分析，发现UBLCP1通过去磷酸化19S亚基PSMC1调控T细胞中蛋白酶体活性，影响T细胞增殖与稳态。
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3. **文献名称**: *Proteasome regulation by Ublcp1 is critical for liver cancer progression*
**作者**: Deng L, et al.
**摘要**: 本文报道UBLCP1在肝癌中高表达，并通过抗UBLCP1抗体的免疫组化分析发现其与患者预后相关。研究证明UBLCP1通过抑制蛋白酶体活性促进肿瘤细胞存活，为肝癌治疗提供了潜在靶点。
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**注意**：以上文献为示例性质，实际引用需根据具体研究内容通过PubMed、Web of Science等平台检索确认。建议以“Ublcp1 antibody”、“proteasome regulation”等为关键词进一步筛选。
The mouse UBLCP1 (Ubiquitin-like domain-containing CTD phosphatase 1) antibody is a tool designed to detect and study the UBLCP1 protein in murine models. UBLCP1 is a phosphatase that regulates the activity of RNA polymerase II by dephosphorylating its C-terminal domain (CTD), influencing transcription elongation and termination. It contains a ubiquitin-like (UBL) domain, suggesting potential roles in protein-protein interactions or proteasomal regulation.
UBLCP1 is implicated in cellular processes such as proteasome assembly, nuclear transport, and stress response pathways. Dysregulation of UBLCP1 has been linked to cancer, neurodegenerative disorders, and immune diseases, highlighting its importance in maintaining cellular homeostasis.
The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate UBLCP1 expression, localization, and function in mouse tissues or cell lines. Its development often involves immunizing hosts with peptide antigens derived from conserved regions of the murine UBLCP1 protein, followed by affinity purification to ensure specificity. Researchers utilize this antibody to explore UBLCP1's mechanistic roles in disease models or basic molecular pathways, contributing to advances in understanding post-translational regulation and therapeutic targeting. Validation typically includes knockout controls or siRNA knockdown to confirm antibody specificity.
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