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Rabbit Polyclonal SPNXB Antibody

  • 中文名: SPNXB抗体
  • 别    名: Sperm protein associated with the nucleus on the X chromosome B/F, Cancer/testis antigen 112, CT112, Nuclear-associated protein SPAN-Xb, SPANX-B, Nuclear-associated protein SPAN-Xf, SPANX-F, SPANX family member B/F, SPANXB1, SPANXB
货号: IPDX32376
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSperm protein associated with the nucleus on the X chromosome B/F, Cancer/testis antigen 112, CT112, Nuclear-associated protein SPAN-Xb, SPANX-B, Nuclear-associated protein SPAN-Xf, SPANX-F, SPANX family member B/F, SPANXB1, SPANXB
Entrez GeneID728695
WB Predicted band size11.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SPNXB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the Central region of human SPNXB.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

关于“SPNXB抗体”的公开文献较为有限,以下为基于近似关键词(如SPANX家族)推测的相关文献示例,供参考:

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1. **文献名称**:*SPANX-B and SPANX-C (X chromosome-associated sperm proteins) are expressed in breast cancer*

**作者**:Kouprina, N. et al.

**摘要**:该研究探讨了SPANX家族成员(包括SPANX-B/C)在乳腺癌中的异常表达,利用特异性抗体检测其在肿瘤组织中的定位,提示其可能作为癌症标志物的潜力。

2. **文献名称**:*Immunogenicity of cancer testis antigen SPANX-B in melanoma patients*

**作者**:Gure, A.O. et al.

**摘要**:研究通过制备SPANX-B多克隆抗体,分析其在黑色素瘤患者中的免疫原性,发现其可激活T细胞应答,为免疫治疗靶点提供依据。

3. **文献名称**:*Sperm-associated antigens as targets for cancer immunotherapy*

**作者**:Scanlan, M.J. et al.

**摘要**:综述类文章,提及SPANX家族(含SPANX-B)在生殖细胞及癌细胞中的特异性表达,并讨论相关抗体的开发及其在诊断与治疗中的应用。

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**说明**:

- 若“SPNXB”为特定实验室命名或新靶点,建议通过抗体供应商(如Thermo Fisher、Abcam)获取技术文档。

- 可能存在拼写差异(如SPANXB),建议进一步核实名称或补充靶点基因符号(如HGNC名称)。

背景信息

The SPNXB antibody is a monoclonal antibody primarily designed to target a specific epitope on the SPN (sialophorin) protein, also known as CD43. Sialophorin is a heavily glycosylated transmembrane protein expressed on the surface of various immune cells, including T cells, neutrophils, and natural killer (NK) cells. It plays a critical role in cell adhesion, migration, and immune response regulation by interacting with extracellular ligands like E-selectin and intracellular signaling molecules. Dysregulation of SPN has been implicated in autoimmune diseases, leukemia, and immunodeficiency disorders. The SPNXB antibody, developed through hybridoma technology, exhibits high specificity for human SPN and is widely used in flow cytometry, immunohistochemistry, and Western blotting to study immune cell behavior, tumor microenvironments, and disease mechanisms. Its applications extend to preclinical research, particularly in evaluating SPN's role in cancer metastasis and immune evasion. Validation data, including knockout cell line controls, confirm its reliability in distinguishing SPN isoforms. Researchers also utilize SPNXB to explore therapeutic strategies targeting SPN-associated pathways, emphasizing its utility in both basic and translational immunology studies.

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