| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein phosphatase inhibitor 2, IPP-2, Ppp1r2, Ipp2 |
| Entrez GeneID | 192361 |
| WB Predicted band size | 23.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This Rat Ppp1r2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-77 amino acids from the Central region of rat Ppp1r2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是假设性的参考文献示例(请注意，实际文献需通过学术数据库查询)：
1. **文献名称**: "Characterization of Ppp1r2 in Rat Testicular Tissues Using a Novel Polyclonal Antibody"
**作者**: K. Yamamoto et al.
**摘要**: 开发了大鼠Ppp1r2多克隆抗体，通过免疫组化证实其在睾丸生精细胞中的高表达，提示其在精子发生中的调控作用。
2. **文献名称**: "Role of Ppp1r2 in Hepatic Glycogen Metabolism: Insights from Antibody-Based Inhibition Studies"
**作者**: M. Chen & R. Gupta
**摘要**: 利用大鼠Ppp1r2抗体阻断其与PP1的相互作用，发现其通过调节磷酸酶活性影响肝细胞糖原合成，提示代谢疾病潜在靶点。
3. **文献名称**: "Ppp1r2 Antibody Reveals Dynamic Localization in Rat Hippocampal Neurons During Synaptic Plasticity"
**作者**: S. Patel et al.
**摘要**: 通过免疫荧光和Western Blot，发现Ppp1r2在大鼠海马神经元突触后区域富集，LTP诱导后表达上调，暗示其参与学习记忆机制。
4. **文献名称**: "Validation of a Commercial Rat Ppp1r2 Monoclonal Antibody for Cardiac Ischemia-Reperfusion Models"
**作者**: J. Müller et al.
**摘要**: 验证某商业抗体在大鼠心脏缺血再灌注模型中的特异性，证实Ppp1r2通过PP1通路调控心肌细胞凋亡。
**建议**：可通过PubMed或Google Scholar搜索关键词“Ppp1r2 antibody rat”或结合具体研究领域(如代谢、神经科学)获取真实文献。
The Rat Ppp1r2 antibody is a research tool designed to detect the protein phosphatase 1 regulatory subunit 2 (Ppp1r2) in rat tissues or cell samples. Ppp1r2 is a regulatory component of protein phosphatase 1 (PP1), a serine/threonine phosphatase critical for diverse cellular processes, including metabolism, cell cycle progression, and signal transduction. Ppp1r2 functions as an endogenous inhibitor of PP1 activity by binding to the catalytic subunit and modulating its interaction with substrates, thereby influencing dephosphorylation events. This regulatory mechanism plays roles in glycogen metabolism, muscle contraction, and neuronal signaling.
The antibody is commonly used in techniques like Western blotting, immunohistochemistry, or immunofluorescence to study Ppp1r2 expression, localization, and function in rat models. Its specificity is validated through knockout controls or peptide-blocking assays to ensure recognition of the target epitope. Researchers employ this antibody to explore Ppp1r2's involvement in physiological or pathological contexts, such as metabolic disorders, neurodegenerative diseases, or cancer, where PP1 dysregulation is implicated. As PP1 activity is tightly controlled by regulatory subunits like Ppp1r2. understanding its expression patterns contributes to deciphering cellular signaling networks and therapeutic targeting strategies.
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