Rabbit Polyclonal SYNJ2 Antibody

Synj2 (synaptojanin 2) is a polyphosphoinositide phosphatase involved in regulating membrane dynamics, endocytosis, and cytoskeletal organization. It shares homology with Synj1 but exhibits distinct tissue expression and functional roles. Synj2 exists in two splice variants: Synj2A, which localizes to the cytoplasm and participates in vesicle trafficking and cell motility, and Synj2B, which associates with mitochondria and influences mitochondrial dynamics. Research has linked Synj2 to cancer progression, particularly in tumor invasion and metastasis, due to its role in modulating actin remodeling and focal adhesion turnover. It also interacts with proteins like endophilin and cofilin, impacting neuronal and non-neuronal cell functions. Antibodies targeting Synj2 are crucial tools for investigating its expression patterns, subcellular localization, and molecular mechanisms in diseases. They are used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore Synj2's involvement in cancers, neurological disorders, and mitochondrial dysfunction. Recent studies also suggest Synj2's potential role in viral entry processes, highlighting its broader relevance in cellular biology and therapeutic targeting.