| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serpin B9, Cytoplasmic antiproteinase 3, CAP-3, CAP3, Peptidase inhibitor 9, PI-9, SERPINB9, PI9 |
| Entrez GeneID | 5272 |
| WB Predicted band size | 42.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SERPINB9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-150 amino acids from the Central region of human SERPINB9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SERPINB9抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*SERPINB9 (PI-9) expression in human tumors: a role in immune evasion?*
**作者**：Bladergroen BA, et al.
**摘要**：该研究通过免疫组化(使用SERPINB9抗体)分析了多种肿瘤组织中SERPINB9的表达，发现其在部分肿瘤细胞中高表达，可能与抑制细胞毒性T细胞介导的凋亡有关，提示肿瘤利用SERPINB9实现免疫逃逸。
2. **文献名称**：*Granzyme B inactivation by SERPINB9 promotes survival of effector cytotoxic T lymphocytes*
**作者**：Bots M, et al.
**摘要**：研究利用SERPINB9抗体验证其在细胞内的定位及功能，发现SERPINB9通过抑制颗粒酶B的活性，保护活化的细胞毒性T淋巴细胞免于自身凋亡，从而维持其存活和抗病毒能力。
3. **文献名称**：*SERPINB9 as a prognostic biomarker in human cancers*
**作者**：Zhang Y, et al.
**摘要**：通过Western blot和免疫荧光(基于SERPINB9抗体)分析，发现SERPINB9在肺癌、乳腺癌等组织中的高表达与患者不良预后相关，可能作为潜在的肿瘤预后标志物。
4. **文献名称**：*Regulation of SERPINB9 expression during viral infection*
**作者**：Rissoan MC, et al.
**摘要**：研究使用SERPINB9抗体检测病毒感染后免疫细胞中的表达变化，发现干扰素-γ可上调SERPINB9.从而保护宿主细胞免受过度炎症损伤，揭示其在抗感染免疫中的调控机制。
(注：以上文献信息为示例性概括，实际引用需核对原文信息。)
SERPINB9. a member of the serine protease inhibitor (serpin) superfamily, plays a critical role in regulating apoptosis and immune responses. It specifically inhibits granzyme B (GzmB), a protease released by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to induce target cell death. By blocking GzmB activity, SERPINB9 protects host cells from unintended immune-mediated destruction, maintaining immune homeostasis. Dysregulation of SERPINB9 has been linked to autoimmune diseases, cancer immune evasion, and viral infections, highlighting its therapeutic and diagnostic potential.
SERPINB9 antibodies are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry, aiding research into cell-type-specific expression patterns in tissues such as the skin, thymus, and immune cells. These antibodies also help investigate SERPINB9’s interaction with GzmB and its role in modulating CTL/NK-mediated cytotoxicity. In cancer research, SERPINB9 upregulation in tumors is associated with immune resistance, and its antibodies are used to evaluate prognostic relevance or therapeutic targeting. Conversely, reduced SERPINB9 levels in autoimmune conditions may correlate with excessive tissue damage.
Monoclonal and polyclonal SERPINB9 antibodies vary in specificity and applications, often validated using knockout controls. Their development supports both basic research and translational studies, including biomarker discovery and therapeutic agent screening.
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