| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neurolysin, mitochondrial, Angiotensin-binding protein, Microsomal endopeptidase, MEP, Mitochondrial oligopeptidase M, Neurotensin endopeptidase, NLN, AGTBP, KIAA1226 |
| Entrez GeneID | 57486 |
| WB Predicted band size | 80.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NLN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of human NLN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NLN(Neurolysin)抗体的3篇代表性文献概览，信息基于公开研究领域常见方向整理：
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1. **文献名称**：*Neurolysin: A Potential Therapeutic Target for Neurological Disorders*
**作者**：Smith A, et al.
**摘要**：探讨Neurolysin在中枢神经系统中的功能，研究团队开发了一种高特异性NLN单克隆抗体，验证其在脑组织中的表达定位，并发现其与神经退行性疾病中异常蛋白降解的相关性。
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2. **文献名称**：*Characterization of a Novel Polyclonal Antibody Against Human Neurolysin*
**作者**：Chen L, et al.
**摘要**：报道了一种新型兔源多克隆抗体的制备，通过免疫印迹和免疫组化验证其特异性，成功应用于检测多种癌症模型中NLN的蛋白表达水平，提示其作为肿瘤标志物的潜力。
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3. **文献名称**：*Neurolysin Knockout Mice Reveal Its Role in Cardiovascular Regulation*
**作者**：Garcia-Rua V, et al.
**摘要**：利用NLN抗体进行组织特异性敲除小鼠模型分析，发现Neurolysin通过调节血管活性肽代谢影响血压稳态，为心血管疾病治疗提供新靶点。
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*注：以上为示例性内容，实际文献需通过学术数据库(如PubMed/Web of Science)检索确认。*
Neurolysin (NLN) is a zinc-metallopeptidase primarily expressed in the central nervous system (CNS) and peripheral tissues, known for its role in cleaving neuropeptides such as neurotensin and opioid peptides. It regulates bioactive peptide signaling, influencing processes like blood pressure modulation, pain perception, and neuroprotection. NLN's enzymatic activity is linked to metabolic homeostasis and recovery from neural injuries, with studies implicating its dysregulation in neurological disorders, including stroke, neurodegenerative diseases, and neuropathic pain.
NLN antibodies are immunological tools designed to detect and quantify NLN expression in research settings. These antibodies enable the study of NLN's spatial and temporal distribution in tissues, its interaction with substrates, and its involvement in disease mechanisms. For instance, Western blotting, immunohistochemistry, and ELISA using NLN antibodies have revealed elevated NLN levels in brain regions post-ischemia, suggesting a compensatory role in neurorepair. Additionally, NLN-targeting antibodies are explored for therapeutic potential, such as modulating neuropeptide degradation pathways or serving as drug carriers.
Recent advancements in antibody engineering, including monoclonal and recombinant formats, have improved specificity and reduced cross-reactivity, enhancing their utility in both basic research and preclinical studies. However, challenges remain in distinguishing NLN from structurally similar enzymes like thimet oligopeptidase. Continued development of NLN-specific antibodies is critical for unraveling its pathophysiological roles and advancing targeted therapies.
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