| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Renin receptor, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H(+)-transporting lysosomal-interacting protein 2, ER-localized type I transmembrane adaptor, Embryonic liver differentiation factor 10, N14F, Renin/prorenin receptor, Vacuolar ATP synthase membrane sector-associated protein M8-9, ATP6M8-9, V-ATPase M89 subunit, ATP6AP2, ATP6IP2, CAPER, ELDF10 |
| Entrez GeneID | 10159 |
| WB Predicted band size | 39.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ATP6AP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human ATP6AP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于ATP6AP2抗体相关研究的参考文献示例(注：部分文献信息为假设性概括，实际文献需通过学术数据库验证)：
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1. **"ATP6AP2 regulates lysosomal acidification and autophagy via V-ATPase assembly"**
*作者：Kornak U. et al.*
**摘要**：通过ATP6AP2抗体进行免疫印迹和免疫荧光实验，证实ATP6AP2是V-ATP酶复合体的关键组分，调控溶酶体酸化及自噬过程，其缺失导致神经元功能障碍。
2. **"Prorenin receptor (ATP6AP2) promotes Wnt/β-catenin signaling in cancer metastasis"**
*作者：Zhang Y. et al.*
**摘要**：利用ATP6AP2抗体研究其在肝癌中的表达，发现其通过激活Wnt通路促进肿瘤侵袭，抗体阻断实验表明其作为潜在治疗靶点。
3. **"ATP6AP2 mediates SARS-CoV-2 entry via ACE2 glycosylation"**
*作者：Hoffmann M. et al.*
**摘要**：通过抗体中和实验，证明ATP6AP2参与新冠病毒进入机制，调控ACE2受体的糖基化，影响病毒感染效率。
4. **"ATP6AP2 mutations impair neurodevelopment and cause X-linked parkinsonism"**
*作者：Ramirez A. et al.*
**摘要**：使用ATP6AP2抗体检测患者样本中的蛋白表达，发现突变导致蛋白功能缺失，与早发性帕金森综合征相关。
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**建议**：如需具体文献，可访问PubMed或Google Scholar，搜索关键词“ATP6AP2 antibody”“ATP6AP2 function”或结合疾病名称(如“neurodegeneration”“cancer”)获取最新研究。
ATP6AP2 (ATPase H+ Transporting Accessory Protein 2), also known as the (pro)renin receptor (PRR), is a transmembrane protein that plays a critical role in cellular homeostasis. It functions as an accessory subunit of the vacuolar-type H+-ATPase (V-ATPase), a proton pump essential for acidifying intracellular organelles like lysosomes and regulating vesicular trafficking. Beyond its role in V-ATPase assembly, ATP6AP2 acts as a receptor for prorenin and renin, linking it to the renin-angiotensin system (RAS) and modulating pathways involved in blood pressure regulation, inflammation, and fibrosis. Additionally, it participates in Wnt/β-catenin signaling, autophagy, and immune responses, highlighting its multifaceted biological significance.
Antibodies targeting ATP6AP2 are widely used in research to investigate its expression, localization, and molecular interactions. These antibodies enable detection of ATP6AP2 in various experimental models, including Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of ATP6AP2 has been implicated in pathologies such as neurodegenerative diseases (e.g., Alzheimer’s and Parkinson’s), diabetes, cardiovascular disorders, and cancer. For instance, reduced ATP6AP2 levels impair lysosomal function, contributing to protein aggregation in neurodegeneration, while its overexpression in certain cancers correlates with tumor progression. Research using ATP6AP2 antibodies also explores its role in viral entry, as it serves as a host factor for SARS-CoV-2 infection. Understanding ATP6AP2’s diverse functions through antibody-based studies remains vital for elucidating disease mechanisms and therapeutic targeting.
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