| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Testin, TESS, TES |
| Entrez GeneID | 26136 |
| WB Predicted band size | 48.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TES antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human TES. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与TES(N-term)抗体相关的文献示例，信息基于公开研究整理：
1. **文献名称**：*TES inhibits cell invasion and metastasis through inactivation of Rho GTPase signaling in hepatocellular carcinoma*
**作者**：Li B. et al.
**摘要**：研究利用TES(N-term)抗体验证TES蛋白在肝癌细胞中的表达，发现其通过调控Rho信号通路抑制肿瘤侵袭，Western blot和免疫组化显示TES低表达与患者预后不良相关。
2. **文献名称**：*The tumor suppressor function of TES in colorectal cancer via modulation of cell adhesion and EMT*
**作者**：Zhang Y. et al.
**摘要**：通过TES(N-term)特异性抗体检测结直肠癌组织中TES的亚细胞定位，证实其通过抑制上皮-间质转化(EMT)发挥抑癌作用，实验包括免疫荧光和Co-IP技术。
3. **文献名称**：*TES interacts with multiple actin cytoskeleton regulators and suppresses melanoma progression*
**作者**：Cheng X. et al.
**摘要**：研究使用TES(N-term)抗体进行免疫沉淀分析，揭示TES与肌动蛋白结合蛋白(如zyxin)的相互作用，阐明其在黑色素瘤中通过稳定细胞骨架抑制转移的机制。
注：以上为模拟示例，实际文献需通过PubMed或Google Scholar以关键词“TES antibody N-terminal”检索获取。
The TES (N-term) antibody is specifically designed to target the N-terminal region of the TES (Testis-derived transcript protein), a cytoskeletal-associated protein implicated in cell adhesion, motility, and tumor suppression. First identified in 2001. TES is encoded by the TES gene located on human chromosome 7q31.1. a region frequently associated with genomic instability in cancers. TES interacts with multiple proteins, including zyxin, mena, and actin, through its LIM domains, playing a role in cytoskeletal organization and focal adhesion dynamics.
In normal tissues, TES is broadly expressed, particularly in testis, ovary, and prostate. Its downregulation or loss is observed in various cancers (e.g., breast, lung, and colorectal), correlating with tumor progression, metastasis, and poor prognosis. The TES (N-term) antibody is widely used in research to study TES expression patterns, subcellular localization, and functional mechanisms via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal region ensures recognition of full-length TES, avoiding cross-reactivity with truncated isoforms. Studies using this antibody have helped elucidate TES's tumor-suppressive roles, including inhibiting cell proliferation, migration, and epithelial-mesenchymal transition (EMT), making it a biomarker candidate and potential therapeutic target in oncology.
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