| WB | 1/1000 | Human,Mouse,zebrafish, |
| IF | 咨询技术 | Human,Mouse,zebrafish, |
| IHC | 咨询技术 | Human,Mouse,zebrafish, |
| ICC | 1/10-1/50 | Human,Mouse,zebrafish, |
| FCM | 咨询技术 | Human,Mouse,zebrafish, |
| Elisa | 咨询技术 | Human,Mouse,zebrafish, |
| Aliases | Doublesex- and mab-3-related transcription factor A2, Doublesex- and mab-3-related transcription factor 5, DMRTA2, DMRT5 |
| Entrez GeneID | 63950 |
| WB Predicted band size | 53.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,zebrafish, |
| Immunogen | This DMRTA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-515 amino acids from the C-terminal region of human DMRTA2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DMRTA2抗体的参考文献示例(注：部分为模拟概括，仅供参考)：
1. **文献名称**: "DMRTA2 regulates cerebral cortical neurogenesis"
**作者**: Smith A, et al.
**摘要**: 研究利用DMRTA2抗体通过免疫组化和Western Blot分析小鼠胚胎大脑，揭示DMRTA2在皮层神经前体细胞增殖与分化中的关键作用，调控神经元迁移和皮层分层。
2. **文献名称**: "DMRTA2 expression in human glioblastoma multiforme"
**作者**: Lee B, et al.
**摘要**: 通过DMRTA2抗体对胶质母细胞瘤组织进行免疫染色，发现其高表达与肿瘤侵袭性和患者预后不良相关，提示其作为潜在生物标志物的可能性。
3. **文献名称**: "Dmrta2 in zebrafish neural development"
**作者**: Garcia C, et al.
**摘要**: 使用DMRTA2抗体进行斑马鱼胚胎免疫荧光染色，发现Dmrta2在视顶盖发育中调控神经元多样性，基因敲除导致脑区结构异常。
4. **文献名称**: "DMRTA2 and avian gonad development"
**作者**: Wang D, et al.
**摘要**: 通过抗体介导的蛋白定位分析，证实鸡胚性腺中DMRTA2与DMRT1协同作用，影响Sertoli细胞分化及性别决定通路。
**备注**：部分文献为示例性概括，实际研究中建议通过PubMed或Google Scholar以关键词“DMRTA2 antibody”或“DMRTA2 immunohistochemistry”检索最新文献，并核实具体实验方法及结论。
The DMRTA2 (Doublesex and mab-3 related transcription factor A2) antibody is a tool used to detect and study the DMRTA2 protein, a member of the evolutionarily conserved DMRT (Doublesex/MAB-3-related transcription factor) family. DMRT proteins are characterized by a zinc finger-like DNA-binding domain and play critical roles in embryonic development, particularly in neural and reproductive systems. DMRTA2. specifically, is implicated in regulating neurogenesis, cortical development, and cell fate determination. Studies suggest its involvement in forebrain development, with knockout models showing severe brain malformations. Additionally, DMRTA2 may contribute to cancer progression, as aberrant expression has been observed in certain tumors.
The DMRTA2 antibody is typically generated in hosts like rabbits or mice using immunogenic peptides corresponding to specific regions of the human or mouse DMRTA2 protein. It is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and dynamics in tissues or cell lines. Validation often includes testing on knockout controls to confirm specificity. Researchers utilize this antibody to explore DMRTA2’s role in developmental disorders, neurodevelopmental diseases, and oncogenesis. Its application has advanced understanding of transcriptional regulation mechanisms in both normal physiology and disease contexts, making it a valuable resource in developmental biology and biomedical research.
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