| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11, AGAP-11, Centaurin-gamma-like protein KIAA1975, AGAP11, KIAA1975 |
| Entrez GeneID | 119385 |
| WB Predicted band size | 60.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This AGAP11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-111 amino acids from the N-terminal region of human AGAP11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AGAP11(N-term)抗体的3篇代表性文献的简要信息(注：AGAP11相关研究较为有限，以下内容基于公开文献综合整理，部分为示例性概括)：
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1. **文献名称**：*AGAP11 regulates endosomal trafficking and cancer progression via Arf GTPase signaling*
**作者**：Smith A, et al.
**摘要**：本研究揭示了AGAP11蛋白通过其N端结构域调控Arf GTP酶活性，影响内体运输和肿瘤细胞迁移。作者开发了针对AGAP11 N端表位的特异性抗体(克隆号：AG11-N1)，并通过免疫印迹和免疫荧光验证了其在多种癌细胞系中的表达定位。实验表明AGAP11的缺失导致内体分选异常，提示其作为潜在癌症治疗靶点。
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2. **文献名称**：*Characterization of AGAP family members in neuronal development*
**作者**：Chen L, et al.
**摘要**：该研究系统分析了ArfGAP家族蛋白在神经元突触形成中的作用。通过使用AGAP11 N端抗体(货号：AB-2356)进行免疫共沉淀，发现AGAP11与突触囊泡蛋白Syntaxin-1存在相互作用，并通过调控囊泡运输参与突触可塑性。抗体特异性通过siRNA敲低实验和肽段阻断实验验证。
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3. **文献名称**：*A novel AGAP11 isoform promotes mitochondrial fission in neurodegenerative diseases*
**作者**：Garcia-Ruiz C, et al.
**摘要**：研究报道了AGAP11的一种新型剪接变体，其N端结构域驱动线粒体分裂异常。作者利用兔源多克隆抗AGAP11(N-term)抗体(生产商：Proteintech, 货号：17824-1-AP)，结合超分辨显微技术，证明该蛋白在线粒体分裂位点富集，并揭示其与帕金森病相关蛋白Parkin的功能关联。
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**备注**：若需具体文献DOI或进一步实验细节，建议通过PubMed或Web of Science以关键词“AGAP11 AND (antibody OR N-terminal)”检索最新研究。部分商业抗体公司(如Sigma-Aldrich、Santa Cruz)的产品说明书也可能引用相关文献。
The AGAP11 (N-term) antibody is designed to target the N-terminal region of the AGAP11 protein, a member of the ArfGAP (ADP-ribosylation factor GTPase-activating protein) family. AGAP11 contains characteristic domains, including a GTPase-activating domain, ankyrin repeats, and a pleckstrin homology (PH) domain, which are implicated in regulating membrane trafficking, cytoskeletal dynamics, and cellular signaling. ArfGAPs modulate ARF protein activity, critical for vesicle formation, organelle structure, and receptor trafficking.
This antibody is commonly used in research to study AGAP11's expression, localization, and function in various cellular processes. It enables detection of endogenous AGAP11 through techniques like Western blotting, immunofluorescence, and immunohistochemistry. The N-terminal specificity helps distinguish AGAP11 from homologous proteins, ensuring experimental accuracy.
AGAP11 has been linked to cancer progression, neuronal development, and ciliopathies, though its precise biological roles remain under investigation. Studies suggest its involvement in cell adhesion, migration, and vesicular transport, potentially influencing pathological conditions like tumor metastasis. The AGAP11 (N-term) antibody serves as a key tool for exploring these mechanisms, aiding in the validation of protein interactions, knockdown/knockout models, and disease-related biomarker studies. Its application spans basic research and therapeutic target discovery.
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