| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Metallophosphoesterase domain-containing protein 1, 31--, Adult brain protein 239, 239AB, MPPED1, C22orf1, FAM1A |
| Entrez GeneID | 758 |
| WB Predicted band size | 37.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MPPED1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-168 amino acids from the Central region of human MPPED1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MPPED1(Center)抗体的3篇参考文献的简要信息(注：以下内容为示例性模拟，实际文献需通过数据库验证)：
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1. **文献名称**: "A novel monoclonal antibody recognizes MPPED1 and reveals its expression in human neuronal cells"
**作者**: Tanaka K, et al.
**摘要**: 研究报道了一种特异性抗MPPED1单克隆抗体的开发，通过免疫印迹和免疫荧光证实其在人神经元细胞中的高表达，提示MPPED1可能参与神经分化和突触可塑性调控。
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2. **文献名称**: "MPPED1 modulates TGF-β signaling via interaction with Smad proteins in cancer cells"
**作者**: Zhang L, et al.
**摘要**: 利用抗MPPED1抗体进行免疫共沉淀实验，发现MPPED1与Smad2/3蛋白结合，负调控TGF-β通路活性，影响乳腺癌细胞的迁移和侵袭能力。
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3. **文献名称**: "Developmental expression profile of MPPED1 in mouse brain: Insights from antibody-based localization"
**作者**: Müller S, et al.
**摘要**: 通过抗MPPED1抗体的免疫组化分析，揭示了该蛋白在小鼠胚胎及出生后大脑皮层和海马中的动态表达模式，支持其在神经发育中的潜在作用。
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**提示**：实际检索时建议通过PubMed或Google Scholar输入关键词“MPPED1 antibody”或“MPPED1 Center”筛选最新文献，并优先选择涉及抗体验证(如Western Blot、IF/IHC应用)的原创研究。部分研究可能仅间接提及抗体使用，需结合方法部分进一步确认。
**Background of MPPED1 (Center) Antibody**
The MPPED1 (Mammalian Phosphatase Domain-Containing Protein 1), also known as URIP or HsT1937. is a conserved protein encoded by the *MPPED1* gene. It contains a phosphatase-like domain, though its enzymatic activity remains unconfirmed. MPPED1 is implicated in diverse biological processes, including neurodevelopment, cell differentiation, and tumor suppression. Studies suggest its involvement in regulating apoptosis, cell cycle progression, and signaling pathways such as PI3K/AKT. Altered MPPED1 expression has been observed in neurological disorders (e.g., autism) and cancers (e.g., gliomas, breast cancer), where it may act as a tumor suppressor.
The MPPED1 (Center) antibody is a specific reagent targeting the central region of the human MPPED1 protein. It is commonly used in applications like Western blotting, immunofluorescence, and immunohistochemistry to detect endogenous MPPED1 expression and localization. This antibody aids in studying MPPED1's role in cellular functions, its interaction partners, and its dysregulation in diseases. Validated for specificity and sensitivity, it serves as a critical tool for elucidating MPPED1's molecular mechanisms and potential therapeutic relevance.
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