Rabbit Polyclonal AKTIP(C-term) Antibody

The AKTIP (C-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the C-terminal region of the AKT-interacting protein (AKTIP), also known as FIP4 or RIP11. AKTIP is a ubiquitously expressed protein involved in various cellular processes, including vesicle trafficking, cell signaling, and apoptosis. It interacts with AKT (protein kinase B), a key regulator of cell survival, proliferation, and metabolism, suggesting a role in modulating AKT pathway activity. The C-terminal domain of AKTIP is critical for its functional interactions, particularly in binding to phosphoinositides and other signaling molecules. Researchers utilize the AKTIP (C-term) antibody primarily in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study AKTIP expression, localization, and protein-protein interactions. Its specificity for the C-terminus ensures minimal cross-reactivity with other regions or proteins, making it a reliable tool for investigating AKTIP's role in cancer, neurodegenerative diseases, and metabolic disorders. Validation typically includes testing on knockout cell lines or tissues to confirm absence of non-specific binding. This antibody has become essential for elucidating AKTIP's regulatory mechanisms in cellular homeostasis and disease pathogenesis.