| WB | DB: 1/500 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mast/stem cell growth factor receptor Kit, SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, CD117, Kit, Sl |
| Entrez GeneID | 16590 |
| WB Predicted band size | 109.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This mouse KIT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S716 of mouse KIT. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Phospho-mouse KIT(S716)抗体的3篇参考文献示例(注：实际文献可能需根据具体数据库检索调整，以下为模拟内容)：
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1. **文献名称**：*KIT phosphorylation at Ser716 regulates stem cell factor-dependent migration in mast cells*
**作者**：Smith A, et al.
**摘要**：该研究通过Phospho-KIT(S716)抗体发现，小鼠肥大细胞中KIT受体在Ser716位点的磷酸化对干细胞因子(SCF)诱导的细胞迁移至关重要，揭示了该位点通过激活下游PI3K信号通路调控细胞运动。
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2. **文献名称**：*Role of phospho-KIT(S716) in melanocyte development and survival*
**作者**：Lee J, et al.
**摘要**：利用Phospho-KIT(S716)特异性抗体，作者证明小鼠黑色素细胞中该位点的磷酸化通过抑制凋亡信号促进细胞存活，并参与胚胎期黑色素前体细胞的发育调控。
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3. **文献名称**：*Ser716 phosphorylation of KIT modulates receptor internalization in leukemic cells*
**作者**：Chen R, et al.
**摘要**：该研究使用Phospho-KIT(S716)抗体发现，小鼠白血病细胞中KIT的Ser716磷酸化负向调控受体内吞作用，影响下游MAPK通路的持续激活，为靶向KIT的药物设计提供了新思路。
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如需获取真实文献，建议在PubMed或Web of Science中检索关键词“Phospho-KIT S716”或“KIT Ser716 phosphorylation”，并筛选物种为小鼠的研究。部分抗体公司(如CST)的产品说明书也会列出引用文献。
The Phospho-mouse KIT(S716) antibody is designed to specifically detect the phosphorylation of serine residue 716 (S716) in the mouse KIT protein, a receptor tyrosine kinase also known as CD117 or stem cell factor receptor. KIT plays critical roles in cell signaling pathways regulating proliferation, survival, and differentiation, particularly in hematopoietic stem cells, mast cells, and germ cells. Phosphorylation at S716 is associated with receptor activation and downstream signaling cascades, including the PI3K/AKT and MAPK pathways, which influence cellular responses to growth factors.
This antibody is widely used in research to study KIT activation dynamics in physiological and pathological contexts, such as cancers (e.g., gastrointestinal stromal tumors) or hematopoietic disorders linked to KIT mutations. By targeting the phosphorylated form, it enables differentiation between active and inactive receptor states, aiding investigations into signaling mechanisms, drug efficacy, or resistance in preclinical models. Validation typically includes Western blotting, immunohistochemistry, or flow cytometry using cell lines or tissues with known KIT activation. Researchers rely on its specificity to explore KIT's role in disease progression and therapeutic targeting, making it a valuable tool for understanding tyrosine kinase signaling in mouse models.
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