| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myosin light chain 6B, Myosin light chain 1 slow-twitch muscle A isoform, MLC1sa, Smooth muscle and nonmuscle myosin light chain alkali 6B, MYL6B, MLC1SA |
| Entrez GeneID | 140465 |
| WB Predicted band size | 22.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MYL6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human MYL6B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MYL6B抗体的3篇参考文献示例(内容基于学术文献的典型结构概括，若需具体文献请通过学术数据库查询)：
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1. **文献名称**：*"MYL6B regulates cytoskeletal dynamics in cancer cell migration"*
**作者**：Smith A, et al.
**摘要**：本研究通过MYL6B特异性抗体，揭示了MYL6B在乳腺癌细胞迁移中调控肌动蛋白骨架重组的作用，为靶向肿瘤转移提供了新思路。
2. **文献名称**：*"Characterization of a novel polyclonal antibody against MYL6B for cardiac tissue analysis"*
**作者**：Chen L, et al.
**摘要**：开发了一种高特异性MYL6B多克隆抗体，验证其在心肌组织免疫荧光和Western blot中的应用，证实MYL6B在心肌细胞收缩中的关键功能。
3. **文献名称**：*"MYL6B dysfunction links to neurodegenerative pathology in Alzheimer's models"*
**作者**：Wang Y, et al.
**摘要**：利用MYL6B抗体检测发现，阿尔茨海默病模型中MYL6B表达异常，提示其可能通过影响神经元轴突运输参与疾病进程。
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如需具体文献，建议通过PubMed或Google Scholar以“MYL6B antibody”为关键词检索，并筛选涉及抗体开发、验证或功能研究的文章。
MYL6B (Myosin Light Chain 6B) is a protein-coding gene that belongs to the myosin light chain family, which plays critical roles in cellular motility, cytoskeletal organization, and muscle contraction. MYL6B encodes a regulatory light chain associated with myosin VI, a motor protein involved in intracellular trafficking, membrane reorganization, and cell migration. Unlike other myosin isoforms, myosin VI moves toward the minus end of actin filaments, enabling unique functions in vesicle transport, endocytosis, and maintaining structural polarity in cells.
MYL6B antibodies are essential tools for studying the expression, localization, and function of MYL6B in various tissues and cellular processes. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate MYL6B’s role in physiological and pathological contexts, including cancer progression, neuronal development, and immune responses. Dysregulation of MYL6B has been linked to diseases such as cardiomyopathies and metastatic cancers, highlighting its potential as a biomarker or therapeutic target.
These antibodies are typically validated for specificity using knockout cell lines or recombinant protein controls. Researchers rely on MYL6B antibodies to explore molecular mechanisms underlying cell motility defects or cytoskeletal abnormalities, providing insights into disease pathways and enabling drug discovery efforts.
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