| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Acyl-CoA-binding domain-containing protein 6, ACBD6 |
| Entrez GeneID | 84320 |
| WB Predicted band size | 31.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ACBD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-78 amino acids from the N-terminal region of human ACBD6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ACBD6 (N-term)抗体的假设性参考文献，供参考：
1. **文献名称**：*"ACBD6 modulates peroxisomal lipid metabolism through N-terminal interactions"*
**作者**：Chen L, et al. (2020)
**摘要**：本研究利用ACBD6 (N-term)特异性抗体，通过免疫印迹和免疫荧光技术，揭示了ACBD6通过其N端结构域与过氧化物酶体膜蛋白相互作用，参与极长链脂肪酸的β-氧化过程。
2. **文献名称**：*"Antibody-based profiling of ACBD6 expression in human tissues"*
**作者**：Martinez S, et al. (2018)
**摘要**：开发并验证了一种针对ACBD6 N端的多克隆抗体，用于检测其在多种人体组织中的表达模式。研究显示ACBD6在肝脏和肾脏中高表达，提示其潜在代谢功能。
3. **文献名称**：*"Functional characterization of ACBD6 in Golgi-ER trafficking using domain-specific antibodies"*
**作者**：Kim D, et al. (2021)
**摘要**：通过N端和C端特异性抗体对比实验，证实ACBD6的N端结构域对维持高尔基体-内质网膜接触位点的稳定性至关重要，并影响鞘脂类合成。
4. **文献名称**：*"ACBD6 knockout mice exhibit altered cholesterol homeostasis"*
**作者**：Watanabe K, et al. (2019)
**摘要**：使用ACBD6 (N-term)抗体验证基因敲除模型，发现ACBD6缺失导致小鼠肝细胞胆固醇酯积累，表明其通过N端介导的蛋白互作调控胆固醇转运。
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注：以上文献为假设性示例，实际引用需查询真实数据库(如PubMed)。若研究较少，可扩展至ACBD6功能研究并提及抗体应用。
The ACBD6 (N-term) antibody is a specialized tool designed to detect the N-terminal region of the acyl-CoA-binding domain-containing protein 6 (ACBD6), a member of the ACBD protein family. ACBD6 is implicated in lipid metabolism, intracellular trafficking, and organelle membrane dynamics by interacting with acyl-CoA esters, which are critical intermediates in fatty acid biosynthesis and modification. The protein contains a conserved acyl-CoA-binding domain (ACBD) at its N-terminus, which facilitates lipid binding and protein-protein interactions.
This antibody is typically generated in immunized hosts (e.g., rabbits or mice) using synthetic peptides or recombinant proteins corresponding to the N-terminal sequence of ACBD6. It is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study ACBD6 expression, subcellular localization (e.g., Golgi apparatus, endoplasmic reticulum), and functional roles in cellular processes such as vesicular transport and lipid homeostasis. Researchers also employ it to explore ACBD6's involvement in diseases linked to lipid dysregulation, including metabolic disorders and cancers. Validation often includes testing on knockout cell lines or tissues to confirm specificity. The antibody's utility lies in its ability to provide insights into ACBD6's regulatory mechanisms and its potential as a therapeutic target.
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