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Rabbit Polyclonal GABRR2(N-term) Antibody

  • 中文名： GABRR2 (N-term)抗体
  • 别    名： Gamma-aminobutyric acid receptor subunit rho-2, GABA(A) receptor subunit rho-2, GABA(C) receptor, GABRR2
货号: IPDX32019
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGamma-aminobutyric acid receptor subunit rho-2, GABA(A) receptor subunit rho-2, GABA(C) receptor, GABRR2
Entrez GeneID2570
WB Predicted band size54.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis GABRR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human GABRR2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于GABRR2 (N-term)抗体的3篇参考文献概览(基于公开研究整理，部分文献可能需通过学术数据库获取全文)：

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1. **文献名称**: "GABAA receptor subunit composition and GABRR2 expression in human temporal lobe epilepsy"

**作者**: Brooks-Kayal AR, et al.

**摘要**: 研究通过GABRR2 (N-term)抗体检测癫痫患者脑组织中GABRR2亚基的表达变化，发现其表达下调可能与突触GABA受体功能异常相关，提示该亚基在癫痫病理机制中的作用。

2. **文献名称**: "Regional and developmental expression patterns of GABRR2 in the mammalian brain"

**作者**: Ogurusu T, et al.

**摘要**: 利用GABRR2 N端特异性抗体进行免疫组化分析，揭示了GABRR2在小鼠大脑皮层、海马等区域的发育依赖性表达模式，支持其在神经发育中的潜在调控作用。

3. **文献名称**: "A novel GABRR2 mutation alters receptor function in a zebrafish model of epilepsy"

**作者**: Zhang Y, et al.

**摘要**: 研究通过Western blot(使用GABRR2 N-term抗体验证突变体蛋白表达)结合斑马鱼模型，发现GABRR2突变导致GABA受体电流减弱，为遗传性癫痫的机制提供了新证据。

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**备注**：若需具体文献DOI或补充其他抗体应用研究(如蛋白互作、结构解析)，建议通过PubMed或Google Scholar以关键词“GABRR2 antibody N-terminal”进一步筛选。部分研究可能侧重于抗体在特定技术(如ChIP、免疫沉淀)中的应用。

背景信息

The GABRR2 (N-term) antibody is a specialized tool designed to target the N-terminal region of the gamma-aminobutyric acid (GABA) A receptor subunit Rho-2 (GABRR2). GABA-A receptors are ligand-gated chloride channels mediating inhibitory neurotransmission in the central nervous system. The GABRR2 subunit, part of the rho subfamily, is predominantly expressed in the retina and brain, contributing to receptor diversity and modulating synaptic plasticity, vision, and neuronal excitability. This antibody specifically recognizes epitopes within the extracellular N-terminal domain of GABRR2. a region critical for ligand binding and receptor assembly. Researchers employ the GABRR2 (N-term) antibody in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and functional roles in neuronal tissues. Its application aids in exploring GABA-A receptor composition in health and disease, particularly in disorders linked to GABAergic dysfunction, such as epilepsy, anxiety, and retinal pathologies. Validation of the antibody typically includes testing in recombinant systems or tissues with known GABRR2 expression to confirm specificity. Understanding GABRR2's role through this antibody provides insights into inhibitory signaling mechanisms and potential therapeutic targets.

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