| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Kelch repeat and BTB domain-containing protein 7, KBTBD7 |
| Entrez GeneID | 84078 |
| WB Predicted band size | 77.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KBTBD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 428-455 amino acids from the Central region of human KBTBD7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KBTBD7抗体的假设性参考文献示例(请注意，这些文献为虚构，仅用于演示格式)：
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1. **文献名称**：*KBTBD7 promotes tumor invasion by ubiquitinating the Notch inhibitor NUMB in colorectal cancer*
**作者**：Zhang, Y., et al.
**摘要**：本研究揭示KBTBD7作为E3泛素连接酶复合物的底物识别组分，通过介导NUMB蛋白的泛素化降解激活Notch信号通路，从而促进结直肠癌转移。研究中利用特异性KBTBD7抗体进行免疫沉淀及组织芯片分析，证实其高表达与患者预后不良相关。
2. **文献名称**：*Structural basis of KBTBD7-CUL3 assembly in substrate recognition*
**作者**：Müller, R., et al.
**摘要**：通过冷冻电镜解析KBTBD7与Cullin3的复合体结构，阐明其底物结合的分子机制。研究团队开发了针对KBTBD7的兔源多克隆抗体，用于验证其在细胞内的定位及与CUL3的相互作用，为靶向泛素化通路的药物设计提供依据。
3. **文献名称**：*KBTBD7 regulates neural crest cell migration during embryonic development*
**作者**：Li, X., et al.
**摘要**：利用斑马鱼模型发现KBTBD7通过调控细胞骨架重塑蛋白的稳定性，驱动神经嵴细胞迁移。通过免疫荧光染色(使用KBTBD7特异性抗体)及基因敲除实验，证实其在胚胎发育中的关键作用，为先天性畸形研究提供新视角。
4. **文献名称**：*KBTBD7 modulates T cell activation through proteasomal degradation of PD-1*
**作者**：Smith, J., et al.
**摘要**：本研究发现KBTBD7在活化的T细胞中特异性表达，并通过降解免疫检查点蛋白PD-1增强抗肿瘤免疫应答。研究中使用人源化KBTBD7单克隆抗体阻断其功能，验证了其作为免疫治疗靶点的潜力。
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如需真实文献，建议通过PubMed或Google Scholar以“KBTBD7 antibody”或“KBTBD7 function”为关键词检索。
The KBTBD7 (Kelch Repeat and BTB Domain-Containing Protein 7) antibody is a tool used to study the function and expression of the KBTBD7 protein, a member of the BTB-Kelch superfamily. KBTBD7 contains a BTB (Broad-Complex, Tramtrack, and Bric-a-brac) domain, which mediates protein-protein interactions, and a Kelch repeat domain involved in substrate recognition. It is implicated in the ubiquitin-proteasome system, potentially acting as a substrate adaptor for Cullin 3 (CUL3)-based E3 ubiquitin ligase complexes to regulate protein degradation. Research suggests KBTBD7 may play roles in cellular processes like apoptosis, inflammation, and cancer progression, with studies linking its dysregulation to tumorigenesis and immune responses.
KBTBD7 antibodies, typically generated in rabbits or mice using immunogenic peptide regions of the protein, enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help characterize KBTBD7's tissue-specific expression, subcellular localization, and interaction partners. Recent investigations explore its involvement in diseases like hepatocellular carcinoma and inflammatory disorders, where it may modulate pathways such as NF-κB or STAT3 signaling. However, the full scope of KBTBD7's biological functions and clinical relevance remains under investigation, necessitating further validation of antibody specificity and functional studies to clarify its mechanistic roles.
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