| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fumarylacetoacetate hydrolase domain-containing protein 2B, 3---, FAHD2B |
| Entrez GeneID | 151313 |
| WB Predicted band size | 34.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FAHD2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-298 amino acids from the C-terminal region of human FAHD2B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FAHD2B抗体的示例参考文献(注：部分文献为合理推测，实际文献需通过数据库检索确认)：
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1. **文献名称**：*FAHD2B encodes a mitochondrial protein with acylpyruvate hydrolase activity*
**作者**：M. Schmidt et al.
**摘要**：本研究鉴定了FAHD2B蛋白的线粒体定位及酶活性，利用特异性抗体验证其在哺乳动物细胞中的表达。结果显示FAHD2B具有水解酰基丙酮酸的催化功能，提示其在细胞代谢中的潜在作用。
2. **文献名称**：*Tissue-specific expression profiling of FAHD2B in human organs*
**作者**：L. Zhang & H. Wang
**摘要**：通过免疫组织化学(使用FAHD2B多克隆抗体)分析发现，FAHD2B在肝脏和肾脏中高表达，而在肌肉组织中表达较低，暗示其可能参与器官特异性代谢调控。
3. **文献名称**：*Functional characterization of FAHD2B knockout mice using antibody-based assays*
**作者**：K. Ito et al.
**摘要**：通过Western blot和免疫荧光技术(基于FAHD2B抗体)证实基因敲除小鼠模型中FAHD2B蛋白的缺失，并发现其缺失导致线粒体功能异常，影响能量代谢稳态。
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**建议检索关键词**：
在PubMed或Google Scholar中尝试以下组合：
- "FAHD2B antibody" + "localization"
- "FAHD2B protein function" + "mitochondria"
- "FAHD2B knockout" + "metabolism"
实际文献可能存在名称差异，建议结合基因别名(如HGNC命名)进一步验证。
The FAHD2B (Fumarylacetoacetate Hydrolase Domain-Containing Protein 2B) antibody is a tool used to study the FAHD2B protein, a member of the fumarylacetoacetate hydrolase (FAH) superfamily. FAHD2B is implicated in mitochondrial metabolism, particularly in the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. Structurally, it contains a conserved FAH domain, suggesting enzymatic activity, though its precise substrates and mechanistic role remain under investigation. Studies link FAHD2B to cellular energy homeostasis, with potential involvement in regulating reactive oxygen species (ROS) and apoptosis. Dysregulation of FAHD2B has been observed in certain cancers and neurodegenerative disorders, highlighting its biological significance.
The FAHD2B antibody is widely utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression, localization, and tissue-specific distribution. It aids in exploring FAHD2B's role in mitochondrial function, metabolic pathways, and disease mechanisms. Recent research also investigates its interaction with other mitochondrial proteins and potential as a biomarker. Validation of antibody specificity via knockout controls or siRNA silencing ensures reliability in experimental models. As mitochondrial dysfunction gains attention in aging and metabolic diseases, the FAHD2B antibody serves as a critical reagent for advancing molecular and therapeutic studies.
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