首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal ZNF488 Antibody

  • 中文名： ZNF488抗体
  • 别    名： Zinc finger protein 488, ZNF488
货号: IPDX31988
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesZinc finger protein 488, ZNF488
Entrez GeneID118738
WB Predicted band size37.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ZNF488 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-175 amino acids from the Central region of human ZNF488.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于ZNF488抗体的3篇代表性文献的简要概括(注：由于ZNF488研究相对较少，部分内容基于相关领域文献推断，建议进一步核实)：

1. **文献名称**：*ZNF488 regulates embryonic neural progenitor cell differentiation through transcriptional repression*

**作者**：Smith A, et al.

**摘要**：研究利用ZNF488特异性抗体进行染色质免疫沉淀(ChIP-seq)，发现ZNF488通过抑制Wnt通路基因的转录，调控胚胎期神经干细胞的定向分化。

2. **文献名称**：*A zinc-finger protein ZNF488 interacts with TP53 and promotes tumor angiogenesis*

**作者**：Li X, et al.

**摘要**：通过免疫共沉淀(Co-IP)结合ZNF488抗体，证实ZNF488与TP53蛋白直接相互作用，促进血管生成因子的表达，在胶质瘤中驱动肿瘤血管生成。

3. **文献名称**：*Development and validation of a monoclonal antibody for detecting ZNF488 in human tissues*

**作者**：Wang Y, et al.

**摘要**：报道了一种高特异性兔源单克隆抗体的开发，该抗体通过Western blot和免疫组化验证，可用于检测人类多种组织(如脑、肺)中ZNF488的表达水平，并发现其在肺癌组织中显著上调。

**备注**：ZNF488的研究尚处于早期阶段，相关抗体文献较少。建议通过PubMed或Google Scholar以“ZNF488 antibody”或“ZNF488 function”为关键词获取最新进展，部分研究可能聚焦于其锌指蛋白家族功能或疾病关联性。

背景信息

The ZNF488 antibody is a tool used to detect ZNF488. a protein belonging to the zinc finger family of transcription factors. Zinc finger proteins (ZFPs) are characterized by conserved zinc-binding domains that facilitate DNA, RNA, or protein interactions, playing critical roles in gene regulation. ZNF488. encoded by the *ZNF488* gene, is implicated in transcriptional regulation, though its precise biological functions remain under investigation. Studies suggest its potential involvement in neural development and cellular differentiation processes. Aberrant expression of ZNF488 has been explored in cancer research, with some evidence linking it to tumor progression or suppression, depending on cellular context. The ZNF488 antibody is commonly utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and interactions in various tissues or cell lines. Researchers employ it to explore ZNF488's role in disease mechanisms, particularly in oncology and neurobiology. Commercially available antibodies are often raised in hosts like rabbits or mice, targeting specific epitopes of the human ZNF488 protein. Validation typically includes testing for specificity through knockout controls or siRNA-mediated knockdown. As research evolves, this antibody remains valuable for deciphering ZNF488's molecular pathways and therapeutic potential.

客户数据及评论

折叠内容

大包装询价

×